Chewable Effervescent Dosage Form for Rapid Relief
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Solution Overview
Problem
Current effervescent antacids fail to provide fast and pleasant relief for heartburn and indigestion due to unpleasant sensory experiences such as chalky taste, lingering aftertaste, toothpacking, and gritty texture, and are often inconvenient to use without water.
Innovation Solution
A chewable effervescent dosage form comprising 26-40% pH neutralization agent, 3-10% acid, and 3-10% effervescent agent, designed to effervesce in the oral cavity, providing quick relief and a pleasant sensory experience without the need for water, with a balanced composition to minimize chalkiness and irritation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If effervescent antacids are made to effervesce strongly to provide pressure relief and signal effectiveness, then the speed of relief and consumer confidence improve, but the taste becomes too salty and/or sour and the effervescence becomes too strong causing unpleasant sensory experience
Solution Approach 1:
The patent applies parameter changes by precisely controlling the composition ratios of acid (3-10%), effervescent agent (3-10%), and pH neutralization agent (26-40%). This balanced formulation adjusts the effervescence intensity to provide noticeable pressure relief while maintaining pleasant taste, avoiding the excessive saltiness and sourness of conventional products.
2Speed
If chewable antacids are formulated to provide fast relief, then the speed of action improves, but the taste becomes chalky and the texture becomes gritty
Solution Approach 1:
The patent uses composite materials by combining pH neutralization agents (such as calcium carbonate or magnesium aluminum silicate) with specific acids and effervescent agents in a balanced formulation. This composite approach maintains the fast-acting antacid properties while the effervescent components and sweeteners mask the chalky taste and reduce gritty texture.
Solution Approach 2:
The patent changes the physical and chemical parameters of the formulation by controlling particle size, moisture content, and composition ratios. These parameter adjustments ensure rapid dissolution for fast relief while minimizing chalkiness and grittiness through optimized formulation.
3Ease of operation
If effervescent products are made to dissolve quickly without water for convenience, then the ease of operation improves, but the effervescence becomes too strong and the taste becomes too salty and/or sour
Solution Approach 1:
The patent applies parameter changes by optimizing the formulation to contain 3-10% acid, 3-10% effervescent agent, and 26-40% pH neutralization agent. This balanced composition allows the tablet to effervesce adequately in the mouth without water while maintaining pleasant taste characteristics and avoiding excessive saltiness or sourness.
4Speed
If liquid antacids are formulated to provide fast relief, then the speed of action improves, but the taste becomes unpleasant and the convenience deteriorates when not at home
Solution Approach 1:
The patent transforms the liquid antacid concept into a chewable effervescent solid dosage form with optimized composition (3-10% acid, 3-10% effervescent agent, 26-40% pH neutralization agent). This provides the fast relief of liquid antacids while improving convenience for use anywhere, eliminating the need to carry liquids or be at home.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The dosage form offers rapid gastrointestinal relief, reduces mouthcoating and aftertaste, and provides a consistent effervescent sensation that is soothing and easy to swallow, offering long-lasting symptom relief while maintaining a pleasant taste and texture.
Implementation Method 1
from 3% to 10% of an acid; and from 3% to 10% of an effervescent agent
Data Source
AI summary
An effervescent chewable dosage form that comprises a pH neutralization agent, an acid, and an effervescent agent. The chewable dosage form can also further comprise simethicone, a sweetener, and a lubricant. The pH neutralization agent can be calcium carbonate, the acid can be citric acid and the effervescent agent can be sodium bicarbonate.