Chewing Gum Formulation for Rapid Cannabinoid Absorption
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Solution Overview
Problem
Current methods for delivering pharmaceutical agents like cannabinoids are limited, particularly for pain treatment, and often involve smoking, which has deleterious effects and is unsuitable for certain populations, while existing formulations may not provide rapid and effective absorption.
Innovation Solution
A novel orally administrable chewing gum formulation comprising a pharmaceutically acceptable gum base and plant material prepared into fine particles, with at least 50% of the particles ranging from 50 to 2000 µm, containing 0.5-30% by weight of pharmaceutical agents such as cannabinoids and terpenes, designed for rapid release and absorption into the circulatory system.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If smoking is used to deliver cannabinoids, then rapid delivery is achieved, but serious deleterious effects and environmental pollution occur
Solution Approach 1:
The patent changes the physical and chemical parameters of the delivery system by using a chewing gum formulation with specific particle size ranges (50-2000 μm) and composition ratios (0.5-30% plant material) to achieve rapid absorption without combustion, eliminating the harmful effects of smoking while maintaining efficient drug delivery
Solution Approach 2:
The chewing gum base acts as an intermediary carrier that facilitates the release and absorption of cannabinoid particles through mastication and saliva interaction, providing a safe alternative to direct combustion while enabling rapid entry into the circulatory system
2Object-affected harmful factors
If conventional chewing gum formulations are used, then safety is improved, but rapid release and absorption are not achieved
Solution Approach 1:
The plant material is segmented into fine particles with specific size distributions (at least 50% by weight in the 50-2000 μm range), which increases the surface area and facilitates rapid release and absorption while maintaining the safety of an orally administrable formulation
Solution Approach 2:
The patent optimizes critical parameters including particle size distribution, plant material concentration (0.5-30% by weight), and gum base composition to achieve both safety and rapid absorption, transforming the conventional chewing gum into an effective pharmaceutical delivery system
3Speed
If particle size is reduced to increase surface area, then absorption rate improves, but manufacturing precision and particle control become more difficult
Solution Approach 1:
The patent defines specific particle size parameters (50-2000 μm range with at least 50% by weight in this range) that balance absorption rate with manufacturability, providing clear specifications that guide processing while ensuring rapid release performance
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The gum formulation enables rapid and effective absorption of pharmaceutical agents, providing a safer and more efficient delivery method compared to smoking, with customizable release rates and improved bioavailability, suitable for various pharmaceutical agents including cannabinoids and terpenes.
Implementation Method 1
A novel orally administrable chewing gum formulation comprising a pharmaceutically acceptable gum base and plant material prepared into fine particles... provides rapid release of the pharmaceutical agents for absorption into the circulatory system
Data Source
AI summary
An orally administrable chewing gum formulation is provided comprising a pharmaceutically acceptable gum base and particles of a pharmaceutical agent ranging in size from about 50 to about 2000 µm, wherein the formulation comprises about 0.5-30% by wt of the pharmaceutical agent particles. A liquid formulation comprising particles of a pharmaceutical agent is also provided.