Chicken Biomarker Panel for Residual Feed Intake Identification
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Solution Overview
Problem
Current methods for measuring residual feed intake in chickens are cumbersome, requiring significant resources and limiting the selection of individuals or populations in breeding, and there is a lack of identified biomarkers for feed efficiency in chickens during the growing period.
Innovation Solution
Identification of biomarkers such as 13-(S)-hydroxyoctatrienoic acid, 20-carboxy-leukotriene B4, Traumatic acid, 15-deoxy-delta-12,14-prostaglandin J2, lysophosphatidylcholine, phosphorycholine, Sphingosine, malic acid, D-4′-Phosphopantothenate, and Spermidine, which are used in kits for detecting residual feed intake through mass spectrometry to improve sensitivity and specificity in breeding for low feed intake.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If the calculation method of residual feed intake is used to evaluate feed efficiency, then feed efficiency can be assessed, but it requires significant manpower and material resources and is difficult to measure in actual production
Solution Approach 1:
The invention extracts specific metabolites (biomarkers) from the complex residual feed intake calculation system. By identifying and measuring specific metabolic characteristics in blood samples, the patent simplifies the assessment process from comprehensive regression analysis to targeted metabolite detection, reducing resource requirements while maintaining assessment accuracy
Solution Approach 2:
The invention introduces metabolic characteristics as an intermediary between feed intake and growth performance. Instead of directly measuring residual feed intake through complex calculations, the patent uses blood metabolites as intermediate indicators that reflect feed efficiency, enabling indirect but accurate assessment with simpler methodology
2Measurement precision
If the calculation method of residual feed intake is used, then feed efficiency can be evaluated, but it limits the selection of individuals or populations in breeding work
Solution Approach 1:
The invention performs preliminary identification of biomarkers associated with feed efficiency before breeding selection. By establishing metabolite profiles that predict feed efficiency early in the growing period, the patent enables breeders to identify suitable individuals for selection programs before committing to specific breeding decisions, increasing flexibility in population selection
Solution Approach 2:
The invention changes the measurement parameter from comprehensive feed intake calculations to specific metabolite concentrations in blood samples. This parameter transformation enables broader application across different breeding programs and populations, as metabolite measurement is more adaptable to various breeding scenarios and requires fewer constraints
3Ease of operation
If blood metabolic characteristics are used to reflect feed efficiency, then biomarkers can be identified, but sensitivity and specificity need to be improved for accurate identification
Solution Approach 1:
The invention combines multiple metabolite measurements into a integrated biomarker panel. By measuring several metabolic characteristics simultaneously and analyzing their combined pattern, the patent enhances both sensitivity and specificity compared to single metabolite assessment, while maintaining the operational simplicity of blood sample analysis
Solution Approach 2:
The invention creates a composite biomarker profile from multiple metabolic indicators. Similar to composite materials in engineering, the patent combines information from different metabolites to create a more robust and accurate identification system, where the combination of markers provides greater precision than individual markers alone
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
These biomarkers significantly differentiate between high and low residual feed intake groups, enhancing the sensitivity and specificity of feed intake identification, enabling a new method for selective breeding and improving feed efficiency without affecting growth.
Implementation Method 1
detecting the biomarkers in chicken serum by mass spectrometry
Data Source
AI summary
The invention discloses biomarkers associated with residual feed intake of growing chickens in growing period and application thereof, which belongs to the field of poultry breeding technology. These biomarkers include one or multiple components of 13(S)-HOTrE, 20-carboxy-LTB4, Traumatic acid, 15-deoxy-delta-12,14-PGJ2, LysoPC(20:2(11Z,14Z)), phosphorycholine, Sphingosine, malic acid, D-4′-Phosphopantothenate, and Spermidine. The invented biomarkers can realize the identification of the residual feed intake, which has high sensitivity and specificity, and is expected to become a new method for the identification of the residual feed intake.