Chimeric Peptide-Modified SIS Membrane for Infectious Bone Defects
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Solution Overview
Problem
Current bone reconstruction methods, such as Guided Bone Regeneration (GBR), face limitations in antibacterial efficacy and soft tissue healing promotion, particularly in addressing infectious bone defects caused by periodontitis and peri-implantitis, despite the use of Small Intestinal Submucosa (SIS) membranes.
Innovation Solution
A chimeric peptide-modified SIS membrane is developed, incorporating specific sequences with high identity to SEQ ID NO: 9, 10, 11, and 12, or their conservative substitutions, which are applied to the SIS membrane surface to enhance antibacterial and osteogenic properties.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If SIS membrane is used for GBR, then mechanical properties and biocompatibility are improved, but antibacterial capability and osteogenesis are limited
Solution Approach 1:
The patent combines SIS membrane with chimeric peptides (containing Hst1 and/or JH8194 sequences) to create a composite material that integrates the excellent mechanical properties and biocompatibility of SIS with the antibacterial and osteogenic capabilities of the peptides, thereby resolving the contradiction between reliability and harmful factors
Solution Approach 2:
The patent modifies the SIS membrane by incorporating specific peptide sequences (Hst1: SEQ ID NO: 1 and JH8194: SEQ ID NO: 2) at controlled concentrations, changing the biochemical parameters of the membrane to enhance antibacterial activity while preserving mechanical integrity
2Strength
If SIS membrane is used for GBR, then mechanical properties are improved, but soft tissue healing promotion is limited
Solution Approach 1:
The chimeric peptide-modified SIS membrane combines the structural strength of SIS with the healing-promoting properties of Hst1 peptide, creating a composite that simultaneously provides mechanical support and accelerates soft tissue regeneration through peptide-mediated cell migration and proliferation
3Strength
If SIS membrane is used for infectious bone defect, then structural support is provided, but antibacterial efficacy is insufficient
Solution Approach 1:
The patent changes the biochemical composition of the SIS membrane by incorporating chimeric peptides containing Hst1 and JH8194 sequences, thereby enhancing the antibacterial parameters while maintaining the structural support function of the original SIS membrane
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The modified membrane effectively inhibits bacterial growth, promotes bone formation, and enhances soft tissue healing, demonstrating improved clinical efficacy in treating infectious bone defects.
Implementation Method 1
a chimeric peptide-modified SIS membrane, wherein the sequence of the chimeric peptide comprises at least one sequence in a group consisting of sequences shown as follows
Data Source
AI summary
A chimeric peptide-modified SIS membrane, a preparation method therefor and an application thereof. The chimeric peptide-modified SIS membrane is used to promote the expression of ITG-α3, ITG-β1, BMP2, RUNX2, ALP and OPN, and inhibits the growth of Streptococcus gordonii and Streptococcus sanguinis, thereby enabling the SIS membrane to exert antibacterial, osteogenic and healing-promoting biological functions. The SIS membrane (that is, a chimeric peptide-modified GBR film) can be used for clinical treatment of infectious bone defects.