Analysis Chip Photometry Correction Using an In-Field Color Plate
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Solution Overview
Problem
Existing analysis apparatuses face inaccuracies in quantitative analysis due to variations in illuminance distribution from light sources, which are influenced by individual differences, installation errors, and light source deterioration.
Innovation Solution
The apparatus incorporates a support section for an analysis chip with a photometry unit that includes a light-emitting element and an area sensor, a color plate within the imaging range, and a processor that corrects measurement values using a correlation between the brightness values of the reaction region and a color plate, derived from pre-photometric and pre-correction brightness values.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a reflective piece is placed within the visual field of the detector to correct reflectivity calculation errors, then measurement precision is improved, but the complexity of the device increases due to additional components and calibration procedures
Solution Approach 1:
The patent merges the reflective piece and color plate into a single integrated component that serves dual purposes: the reflective piece provides reflectivity reference while the color plate provides illuminance distribution reference. This integration eliminates the need for separate calibration components and reduces overall device complexity while maintaining measurement precision.
Solution Approach 2:
The color plate serves multiple functions simultaneously: it acts as a reflectivity standard, an illuminance distribution reference, and a calibration target. This multi-functionality reduces the number of separate components needed and simplifies the overall measurement system while improving optical density calculation accuracy.
2Measurement precision
If a standard reflective piece is used to correct reflectivity variation, then measurement precision is improved, but the accuracy is still lowered due to variation in illuminance distribution of light from the light source
Solution Approach 1:
The color plate acts as an intermediary element that references the illuminance distribution of the light source. By measuring the brightness of the color plate under the same lighting conditions, the system can compensate for illuminance variations and improve the reliability of reflectivity measurements without requiring complex real-time calibration.
Solution Approach 2:
The system performs preliminary measurement of the color plate brightness to establish a reference for illuminance distribution. This preliminary action allows the system to pre-calculate correction factors that can be applied during subsequent measurements, ensuring accurate optical density calculation while accounting for light source variations.
3Device complexity
If quantitative analysis is performed without correcting for illuminance distribution variation, then device complexity is reduced, but measurement precision deteriorates
Solution Approach 1:
The color plate enables the system to self-correct for illuminance distribution variations by providing an internal reference. The system uses the color plate brightness measurement to automatically calculate and apply correction factors, achieving accurate quantification without requiring external calibration equipment or complex manual procedures.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables high-accuracy quantitative analysis by correcting for variations in illuminance distribution, ensuring precise measurement even with changes in light source conditions.
Implementation Method 1
a light-emitting element that irradiates the reaction region of the analysis chip with measurement light
Implementation Method 2
an area sensor that captures an image of a predetermined imaging range including the reaction region irradiated with the measurement light
Implementation Method 3
a color plate arranged within the imaging range and having a region irradiated with the measurement light
Data Source
AI summary
An analysis apparatus includes: a support section that supports an analysis chip at a measurement position; a photometry unit including a light-emitting element that irradiates a reaction region of the analysis chip with measurement light, and an area sensor that captures an image of a predetermined imaging range including the irradiated reaction region; a color plate arranged within the imaging range and having a region irradiated with the measurement light; and a processor that performs quantitative analysis of a detection target substance based on a measurement value corresponding to a photometric region brightness value extracted from an image acquired from the photometry unit, and extracts a correction brightness value of the color plate to correct the measurement value based on the correction brightness value and a correlation between a pre-photometric region brightness value acquired in advance using a reference plate, and a pre-correction brightness value of the color plate.