Chiral Separating Agent for Amino Acid Resolution

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Solution Overview

Problem

Conventional methods for optical resolution of amino acids face challenges in achieving identical elution orders and high resolution between D-bodies and L-bodies, leading to interference from peptides and amino compounds, and limitations in peak separation using mass spectrometry and existing chromatographic techniques.

Innovation Solution

A separating agent with specific chemical groups introduced on its surface, such as those represented by chemical formulas , or , is used to improve peak resolution by condensing compounds like or with substrates having amino groups, forming amide linkages and enhancing the separation of D-bodies and L-bodies in amino acids.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Manufacturing precision

If conventional chromatographic techniques are used for optical resolution of amino acids, then separation can be achieved, but the elution order of D-bodies and L-bodies is not identical and resolution between peaks is low

Engineering Contradiction:
Improveresolution between peaksVSAvoididentical elution order
Core Design Contradiction:
Manufacturing precisionVSReliability

Solution Approach 1:

The patent modifies the chemical structure of the stationary phase by introducing specific chiral selectors (Pirkle-type selectors with aromatic rings and hydrogen bonding groups) to change the interaction parameters between the selector and amino acid enantiomers. This structural parameter change enables both identical elution order and high peak resolution for D- and L-amino acids.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The invention creates a composite stationary phase by combining chiral selectors (such as 3,5-dinitrobenzoyl leucine derivatives) with silica gel support material. This composite structure provides both the chiral recognition capability for identical elution order and the surface area for high peak resolution through multiple interaction sites.

Inventive Principle:
Principle #40Composite materials

2Measurement precision

If mass spectrometry is used for high resolution analysis, then analysis resolution is improved, but separation of enantiomers is impossible in principle

Engineering Contradiction:
Improveanalysis resolutionVSAvoidenantiomer separation
Core Design Contradiction:
Measurement precisionVSManufacturing precision

Solution Approach 1:

The patent divides the analytical process into two distinct stages: first, chiral separation of enantiomers using the specialized HPLC column with Pirkle-type selectors, and second, high-resolution mass spectrometric analysis of the separated enantiomers. This segmentation allows each technique to perform its optimal function - separation and then detection.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The chiral stationary phase acts as an intermediary that converts the indistinguishable enantiomers into separable species by creating diastereomeric interactions through hydrogen bonding and π-π interactions. This intermediary step enables subsequent mass spectrometry to detect and quantify individual enantiomers that would otherwise be indistinguishable.

Inventive Principle:
Principle #24Intermediary (Mediator)

3Manufacturing precision

If conventional HPLC columns are used for optical resolution, then separation can be performed, but interference from peptides or amino compounds occurs

Engineering Contradiction:
Improveoptical resolutionVSAvoidinterference from peptides
Core Design Contradiction:
Manufacturing precisionVSObject-affected harmful factors

Solution Approach 1:

The patent introduces specific functional groups (hydrogen bonding groups, aromatic rings) at specific locations on the stationary phase surface to create localized chiral recognition sites. These localized sites provide selective interactions with amino acid enantiomers while being less susceptible to interference from larger peptide molecules, enabling specific optical resolution.

Inventive Principle:
Principle #3Local quality

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The solution enables identical elution orders and improved peak resolution between D-bodies and L-bodies, achieving high chemical and optical purity, as demonstrated by high performance liquid chromatography results with peak-to-valley ratios greater than or equal to 2.0 and symmetry coefficients less than 4.0.

Implementation Method 1

a group represented by a chemical formula of: (1) or a group represented by a chemical formula of: (2) is introduced on a surface thereof

Methodology Applied
Scientific EffectChiral recognition:

Implementation Method 2

which has a step of condensing a compound represented by a chemical formula of: (3) or a compound represented by a chemical formula of: (4) with a substrate with an amino group being present on a surface thereof

Methodology Applied
Scientific EffectCondensation reaction:

Data Source

PatentEP2811295B1Separating agent and method for manufacturing same
Publication Date: 2019.03.13 SHISEIDO CO LTD
  • EP2811295B1 patent drawingFigure 1
  • EP2811295B1 patent drawingFigure 2
  • EP2811295B1 patent drawingFigure 3

AI summary

An embodiment of the present invention is a separating agent wherein a group represented by a chemical formula of: or a group represented by a chemical formula of: is introduced on a surface thereof.