Chitooligomer Composition for Tissue Regeneration and Anti-Inflammation
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current biomaterials for tissue healing and regeneration are limited in their active contribution to the biologic processes involved in tissue repair and regeneration, often leading to chronic inflammation and impaired tissue function due to passive roles and debris-related issues.
Innovation Solution
A composition of therapeutically active chitooligomers (T-ChOS) and glucosamine, with specific chain lengths and ratios, that synergistically promote tissue regeneration and anti-inflammation by interacting with Chitinase-Like Proteins, enhancing collagen synthesis and bioavailability, and reducing the presence of degradative debris.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If first generation biomaterials are used for tissue support, then mechanical strength is achieved, but chronic inflammation and debris release occur
Solution Approach 1:
The patent extracts and removes the harmful degradative debris generation mechanism by using fully acetylated chitin oligomers with controlled chain lengths (DP 4-20) that resist enzymatic degradation. This extraction eliminates the source of chronic inflammation while maintaining mechanical support function.
Solution Approach 2:
The patent changes the chemical parameters of the biomaterial by using fully acetylated chitin oligomers with specific degree of acetylation (100%) and controlled molecular weight (DP 4-20). These parameter changes transform the material from debris-generating to biostable, eliminating harmful degradation products while maintaining structural integrity.
2Object-generated harmful factors
If second generation biodegradable biomaterials are used, then chronic inflammation is reduced, but active contribution to tissue healing is limited
Solution Approach 1:
The patent applies self-service by incorporating bioactive molecules (growth factors, cytokines) directly into the chitin oligomer structure, enabling the material to actively promote tissue healing through its own intrinsic properties rather than passively supporting degradation. The material serves both structural and biological functions simultaneously.
Solution Approach 2:
The patent creates composite materials by combining chitin oligomers with bioactive molecules such as growth factors, cytokines, and extracellular matrix components. This composite structure provides both the mechanical support of the biomaterial and the active biological signaling needed for enhanced tissue regeneration and healing.
3Strength
If passive biomaterials are used for tissue replacement, then structural support is provided, but regenerative effects are impaired
Solution Approach 1:
The patent applies preliminary action by pre-incorporating bioactive molecules and growth factors into the chitin oligomer structure before implantation. This preliminary preparation ensures that the material is already equipped with regenerative signals that will actively promote tissue healing from the outset, rather than requiring subsequent biological processes to generate these signals.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively promotes tissue regeneration, reduces inflammation, and enhances collagen type II formation, demonstrating significant regenerative and anti-inflammatory effects in both in vitro and in vivo models, particularly in conditions like rheumatoid arthritis, while avoiding the limitations of passive biomaterials.
Implementation Method 1
The composition effectively promotes tissue regeneration, reduces inflammation, and enhances collagen type II formation, demonstrating significant regenerative and anti-inflammatory effects in both in vitro and in vivo models
Implementation Method 2
A composition of therapeutically active chitooligomers (T-ChOS) and glucosamine, with specific chain lengths and ratios, that synergistically promote tissue regeneration and anti-inflammation
Implementation Method 3
the combination of T-ChOS and glucosamine constitutes an active agent for promoting and enhancing collagen type II formation in cartilage explants, apparently through interaction with YKL-40, a member of the CLP protein family
Data Source
Figure 1~2
Figure 3~4
Figure 5~6
AI summary
The present invention relates to a composition, use and a method for reducing inflammation and promoting tissue repair or tissue regeneration through a synergistic effect of T-ChOS and Glucosamine and/or N-acetyl glucosamine systemically or locally administered in humans and other mammals in need thereof.