Chitosan Derivative Acicular Body Non-Acidic Solvent
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Solution Overview
Problem
Acicular bodies made of chitosan manufactured using acidic solutions can be harmful as they dissolve in the body, releasing substances other than the intended drug, posing risks to the body.
Innovation Solution
The development of an acicular body using chitosan derivatives like chitosan succinamide, carboxymethyl chitosan, or trimethyl chitosan, which are soluble in water without requiring acidic solutions, allowing for the incorporation of a substance to be delivered bonded via an ester bond, ensuring biocompatibility and reduced risk of interaction with the body.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If chitosan is dissolved in water using acidic aqueous solution, then the acicular body can be manufactured, but the acidic compound remains in the acicular body causing harm when dissolved in the body
Solution Approach 1:
The patent changes the chemical parameters of the solvent system by replacing acidic aqueous solution with a non-acidic solvent system comprising water and organic solvent. This parameter change allows chitosan to be dissolved and processed without introducing harmful acidic compounds, thereby resolving the contradiction between manufacturability and biocompatibility.
Solution Approach 2:
The patent converts the traditionally harmful acidic dissolution process into a beneficial non-acidic process. By using organic solvents that can dissolve chitosan without acidity, the method transforms a harmful manufacturing approach into a safe one, eliminating the harmful effect while maintaining the ability to manufacture the acicular body.
2Quantity of substance
If acidic aqueous solution is used to dissolve chitosan, then the acicular body can be formed, but substances other than the intended drug are dissolved into the body
Solution Approach 1:
The patent changes the chemical environment parameters by introducing organic solvents (alcohols, ketones, esters, or their mixtures) to create a non-acidic dissolution medium. This parameter change enables chitosan to achieve sufficient solubility for acicular body formation without the presence of acidic compounds that would otherwise be released into the body.
3Reliability
If chitosan is used without modification, then the material is biocompatible, but it requires acidic solution for dissolution which creates harm
Solution Approach 1:
The patent introduces organic solvents as intermediary substances that mediate between chitosan and water. These intermediaries enable chitosan to dissolve in a non-acidic environment by acting as a bridge that facilitates dissolution without requiring acidic conditions, thus maintaining biocompatibility while improving the manufacturing process.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The acicular body can be manufactured without acidic compounds, ensuring biocompatibility and effective delivery of substances like pharmacological agents and cosmetic compositions, with enhanced solubility and reduced risk of harm to the body.
Implementation Method 1
chitosan has a property of being insoluble in water but soluble in acidic aqueous solution
Data Source
Figure 1~4
AI summary
An acicular body according to the present invention includes a support base, and a needle disposed on the support base and formed containing a chitosan derivative.