Chitosan Coated Medical Stent Wall Electrodeposition
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing methods for coating medical products, such as stents, with polymers like chitosan often result in layer fractures when the product changes shape, and may not be suitable for hollow structures due to the risk of occlusions and adverse reactions in the body.
Innovation Solution
A method involving electrodeposition of a polymer, specifically chitosan, from an acidic mixture onto the inner and outer surfaces of hollow medical products, ensuring the polymer layer remains intact during shape changes and minimizes material usage, while also allowing for the incorporation of bioactive agents.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a polymer coating is applied to the inside of hollow medical products using conventional methods, then the coating provides biocompatibility, but the coating layer may fracture when the product changes shape
Solution Approach 1:
The patent applies electrodeposition parameters (voltage, current density, deposition time) to control the polymer coating properties. By optimizing these parameters, the coating achieves both integrity and flexibility, resolving the contradiction between coating strength and flexibility during shape changes
Solution Approach 2:
The patent uses composite polymer coatings (e.g., chitosan combined with other polymers or materials) that inherently provide both mechanical strength and flexibility. This composite approach allows the coating to maintain integrity while accommodating shape changes of the hollow medical product
2Reliability
If a thick polymer coating is applied to ensure complete coverage, then biocompatibility is improved, but material usage increases and occlusion risk rises
Solution Approach 1:
The patent replaces conventional mechanical coating methods (dip-coating, spray-coating) with electrodeposition. This electrical field-based method enables precise control of coating thickness and uniform distribution, achieving complete coverage with minimal material usage and reducing occlusion risk
Solution Approach 2:
By controlling electrodeposition parameters (current density, deposition time, voltage), the patent optimizes coating thickness to provide sufficient biocompatibility while minimizing polymer material usage and preventing occlusions in the hollow structure
3Ease of manufacture
If conventional coating methods are used, then coating application is simple, but the coating may not adhere properly to hollow structures and may cause occlusions
Solution Approach 1:
The patent replaces mechanical coating adhesion mechanisms with electrostatic attraction during electrodeposition. The electrical field ensures uniform and strong adhesion of the polymer coating to the hollow structure surface, preventing delamination and occlusions while maintaining manufacturing simplicity
Solution Approach 2:
The electrodeposition process allows the coating to self-assemble and self-adhere to the hollow structure through electrostatic forces. This self-organizing mechanism ensures proper adhesion without complex manual intervention, maintaining ease of manufacture while improving coating reliability
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method achieves a flexible, thin, and even polymer layer that reduces occlusions and adverse reactions, enhancing biocompatibility and preventing thrombosis, suitable for various medical applications including drug-eluting stents.
Implementation Method 1
at least the part of the inside of the wall of the medical product brought into contact with a mixture, preferably a solution, of the polymer, and the polymer precipitates from the mixture to be deposited on at least the part of the inside of the wall
Implementation Method 2
the polymer precipitates from the mixture to be deposited on at least the part of the inside of the wall
Data Source
AI summary
A method for manufacturing a medical product comprising a hollow body (2), wherein at least part of a wall of the hollow body (2) is coated at least on the inside with a layer comprising a polymer; at least the part of at least the inside of the wall of the medical product is brought into contact with a mixture (6) of the polymer and the polymer is deposited from the mixture (6) on at least the part of the inside of the wall. And a medical product comprising a hollow body (2) with a wall consisting of one or more structural elements (16), at least a section of the wall being coated with a layer (15) comprising native chitosan, wherein both on the inside and the outside of the hollow body (2) at least some of the one or more structural elements (16) of the wall of the hollow body (2) are at least partly coated with the native chitosan layer (15). And a method for electrodepositing a polymer on an electrode from an acidic mixture of the polymer, wherein the mixture (6) comprises a multibasic acid.