Chitosan Hemostatic Dressing Delivery for TURP Bleeding Control
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Solution Overview
Problem
Current methods for controlling bleeding during and after transurethral resection of the prostate (TURP) are inadequate, particularly for venous oozing, leading to prolonged hospital stays, increased costs, and complications in anti-coagulated patients, with existing dressings failing to effectively address the unique challenges of bladder and prostate bleeding.
Innovation Solution
A chitosan endoluminal hemostatic dressing delivery device with a distal and proximal balloon system is used to deliver a chitosan dressing to the injury site, which adheres to tissue upon wetting and controls bleeding effectively, allowing for rapid hemostasis and reduced catheterization time.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If balloon pressure is applied for prolonged periods to control venous oozing, then bleeding control is improved, but patient discomfort and hospital stay are prolonged
Solution Approach 1:
The chitosan dressing is applied to the prostatic cavity before the patient leaves the operating room, providing immediate hemostatic action. The dressing adheres to the tissue and controls bleeding proactively, eliminating the need for prolonged postoperative balloon catheterization and reducing hospital stay.
Solution Approach 2:
The chitosan dressing acts as an intermediary hemostatic agent between the surgical procedure and prolonged balloon pressure application. It provides effective bleeding control while allowing earlier removal of the balloon catheter, thus reducing patient discomfort and hospitalization time.
2Reliability
If electrocautery is used for arterial bleeding control, then hemostasis is achieved, but tissue necrosis increases
Solution Approach 1:
The chitosan dressing provides mechanical hemostasis through adhesion to the tissue and physical compression of bleeding vessels, replacing the need for electrocautery's thermal mechanism. This substitution eliminates thermal damage and tissue necrosis while achieving effective hemostasis.
Solution Approach 2:
The invention changes the hemostatic mechanism from thermal (electrocautery) to mechanical/chemical (chitosan adhesion and compression). The dressing's ability to adhere to wet tissue and provide sustained pressure achieves hemostasis without the harmful thermal effects of electrocautery.
3Reliability
If standard hemostasis methods are used in anti-coagulated patients, then bleeding control becomes unpredictable, but surgical intervention complexity increases
Solution Approach 1:
The chitosan dressing is a disposable, easily applied hemostatic agent that provides reliable bleeding control in anti-coagulated patients without requiring complex surgical interventions. Its straightforward application and predictable effectiveness simplify the overall surgical process.
Solution Approach 2:
The chitosan dressing changes the bleeding control mechanism to one that is independent of the patient's coagulation status. Its adhesion-based hemostasis works reliably in anti-coagulated patients, providing predictable outcomes without increasing surgical complexity.
4Reliability
If prolonged balloon catheterization is used to control bleeding, then hemostasis is maintained, but patient discomfort and morbidity increase
Solution Approach 1:
The chitosan dressing is applied during the surgical procedure to control bleeding before the patient experiences prolonged catheterization discomfort. This preliminary hemostatic action allows for earlier removal of the balloon catheter, significantly reducing patient discomfort and morbidity.
Solution Approach 2:
The chitosan dressing serves as an intermediary that provides effective bleeding control, enabling earlier discontinuation of balloon catheterization. This reduces the duration of patient discomfort associated with prolonged catheter presence while maintaining reliable hemostasis.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device provides rapid and sustained hemostasis, reducing patient discomfort, hospital stay, healthcare costs, and morbidity, and enabling outpatient procedures by effectively controlling bleeding in anti-coagulated patients.
Implementation Method 1
a chitosan endoluminal hemostatic dressing delivery device with a distal and proximal balloon system is used to deliver a chitosan dressing to the injury site, which adheres to tissue upon wetting
Implementation Method 2
the distal balloon, when inflated, can be used to position the proximal balloon and the CEHD with low tension along the delivery device
Implementation Method 3
the proximal balloon can be inflated to deliver the CEHD to an injury site
Data Source
AI summary
The present disclosure relates to a gastrointestinal delivery device of a chitosan dressing, where the delivery device is capable of stop bleeding, in particular in connection with TURP procedures. The delivery device may be used in all gastrointestinal bleeding applications and can be used with a biocompatible, foldable, thin profile, chitosan dressing. Various aspects of the device and its uses are provided herein.