Chitosan-Polysaccharide Matrix Viscosity Stability
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Solution Overview
Problem
Biocompatible products for filling, replacing, or increasing biological tissue volume or supplementing biological fluids face challenges with undesirable side effects and weak efficacy, particularly due to degradation in rheological properties after heat treatment, which is necessary for sterilization.
Innovation Solution
A biocompatible product is developed by co-crosslinking polysaccharides like hyaluronic acid with chitosan and incorporating divalent zinc cations, which enhances viscosity and maintains it after heat treatment, thereby improving durability and suitability for medical and cosmetic applications.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If crosslinked hyaluronic acid or salt of crosslinked hyaluronic acid is used to create biocompatible products, then the product exhibits satisfactory viscosity after crosslinking, but the viscosity tends to decrease sharply after heat treatment such as autoclave sterilization
Solution Approach 1:
The patent combines hyaluronic acid with chitosan or its derivatives to create a composite hydrogel material. This composite structure leverages the complementary properties of both polymers: hyaluronic acid provides the base viscosity and biocompatibility, while chitosan enhances thermal stability and prevents viscosity degradation during autoclave sterilization. The synergistic interaction between these two biopolymers resolves the contradiction by maintaining both satisfactory initial viscosity and heat treatment stability.
Solution Approach 2:
The patent modifies the chemical composition parameters of the hydrogel by incorporating chitosan derivatives with specific molecular weights and degrees of deacetylation. By adjusting these parameters, the product achieves optimal balance between initial viscosity and thermal stability. The presence of chitosan alters the crosslinking network structure, creating a more thermally resistant gel matrix that maintains its rheological properties after autoclave sterilization.
2Reliability
If the viscosity of the product is increased to improve efficacy, then the product can better fill and replace biological tissue, but the product becomes more susceptible to degradation following heat treatment
Solution Approach 1:
The patent creates a composite hydrogel system where chitosan reinforces the hyaluronic acid matrix, enabling the product to achieve high viscosity while maintaining thermal stability. The dual-polymer structure provides both the necessary rheological properties for effective tissue filling and the thermal resistance needed to withstand autoclave sterilization without significant viscosity loss.
3Object-affected harmful factors
If heat treatment such as autoclave sterilization is applied to sterilize the product, then the product is safe for use in humans or animals, but the viscosity of the product decreases sharply
Solution Approach 1:
The patent develops a composite hydrogel formulation where chitosan acts as a thermal stabilizer during autoclave sterilization. This composite structure allows the product to undergo standard sterilization procedures while maintaining its rheological properties, thus achieving both sterility and functional integrity.
Solution Approach 2:
The patent incorporates chitosan into the hydrogel formulation in advance to provide protective cushioning against thermal degradation. This pre-built protective mechanism prevents viscosity collapse during the subsequent autoclave sterilization process, ensuring the product remains effective after sterilization.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The product achieves high viscosity that is maintained or even increased after heat treatment, enhancing its effectiveness for filling, replacing, or supplementing biological tissues or fluids, and reducing the risk of degradation, making it suitable for various medical and cosmetic uses.
Implementation Method 1
co-crosslinking of a polysaccharide with chitosan, a chitosan derivative or a salt of chitosan, which leads to the establishment of covalent bonds in the matrix between the polysaccharide and the chitosan
Implementation Method 2
the presence of a divalent zinc cation, not only significantly increases the viscosity of the product, but moreover effectively limits the decrease in viscosity after heat treatment such as autoclaving
Implementation Method 3
this is generally achieved by heat treatment (for example, in an autoclave)
Implementation Method 4
heat treatment such as autoclave sterilization
Data Source
AI summary
The invention relates to a biocompatible product having a crosslinked matrix, in which a polysaccharide is co-crosslinked with chitosan, a chitosan derivative, or a salt of chitosan, said matrix further comprising a divalent zinc cation.