Chlorhexidine Antiseptic Composition for Sustained Skin and Fabric Action

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Solution Overview

Problem

Chlorhexidine-based antiseptic compositions exhibit low solubility and stability in water, leading to decreased antibacterial persistence upon application to the skin, and there is a need to improve their absorption efficiency and stability on fabric bases.

Innovation Solution

Incorporation of a silicone-based emulsifier and a polyglyceryl fatty acid ester into the antiseptic composition, which includes chlorhexidine or its derivatives, to enhance solubility, stability, and sustained release, thereby maintaining antibacterial efficacy.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of manufacture

If chlorhexidine or derivative is used in water-soluble form, then ease of manufacture and application is improved, but antibacterial persistence decreases

Engineering Contradiction:

Improvewater solubilityVSAvoidantibacterial persistence

Core Design Contradiction:

Ease of manufactureVSDuration of action of moving object

Solution Approach 1:

The patent combines chlorhexidine with a specific copolymer consisting of polyethylene glycol and polypropylene glycol units to create a composite material system. This copolymer-chlorhexidine complex provides both water solubility and sustained release capability, resolving the contradiction between ease of manufacture and antibacterial persistence. The copolymer acts as a carrier that maintains solubility while enabling controlled release of the active ingredient.

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent modifies the molecular structure parameters of the polymer carrier by controlling the ratio of polyethylene glycol to polypropylene glycol units and adjusting the molecular weight range (10,000-1,000,000). These parameter changes optimize the balance between water solubility and release rate, allowing the composition to maintain both ease of manufacture and prolonged antibacterial action.

Inventive Principle:

Principle #35Parameter changes

2Reliability

If chlorhexidine concentration is increased to improve antibacterial action, then bactericidal effectiveness is improved, but solubility and stability in water deteriorate

Engineering Contradiction:

Improvebactericidal actionVSAvoidwater solubility and stability

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

The copolymer serves as an intermediary carrier that solubilizes high concentrations of chlorhexidine in water. The polymer chains interact with chlorhexidine molecules through hydrophobic and hydrophilic interactions, forming stable complexes that remain soluble at higher active ingredient concentrations. This mediator approach allows achieving high bactericidal effectiveness while maintaining water solubility and compositional stability.

Inventive Principle:

Principle #24Intermediary (Mediator)

3Duration of action of stationary object

If antiseptic composition is applied to fabric base, then duration of action is improved, but absorption efficiency decreases due to adsorption

Engineering Contradiction:

Improveduration on fabricVSAvoidabsorption efficiency

Core Design Contradiction:

Duration of action of stationary objectVSQuantity of substance

Solution Approach 1:

The copolymer structure provides different local properties: the polyethylene glycol segments interact with fabric surfaces to ensure proper adhesion and distribution, while the polypropylene glycol segments control the release kinetics. This local quality differentiation within the copolymer chain allows the composition to be effectively absorbed by fabric while maintaining sufficient quantity for prolonged antibacterial action.

Inventive Principle:

Principle #3Local quality

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition achieves improved antibacterial persistence with enhanced absorption efficiency and reduced adsorption to fabric bases, maintaining effective antibacterial action over time and improving production efficiency.

Implementation Method 1

Incorporation of a silicone-based emulsifier and a polyglyceryl fatty acid ester into the antiseptic composition, which includes chlorhexidine or its derivatives, to enhance solubility

Methodology Applied

Scientific EffectEmulsification: Emulsion

Implementation Method 2

Methodology Applied

Scientific EffectDiffusion: Diffusion

Implementation Method 3

Methodology Applied

Scientific EffectSurface tension reduction: Surfactant

Data Source

PatentUS12544346B2Aqueous antiseptic composition having improved antibacterial persistence comprising chlorhexidine or derivative thereof and fabric type antiseptic comprising same

Publication Date: 2026.02.10 HUONS MEDITECH CO LTD

AI summary

The present invention relates to: an aqueous (a water-soluble) antiseptic composition having improved antibacterial persistence comprising chlorhexidine or a derivative thereof and a silicon-based emulsifier; and a fabric type antiseptic comprising same. As the chlorhexidine or the derivative thereof is highly soluble and stable and well dispersed in an aqueous phase, the composition can exhibit excellent absorption efficiency when applied onto the skin and can ultimately maximize a cumulative emission amount of chlorhexidine or the derivative thereof. In addition, the use of the polyglyceryl fatty acid ester allows sustained release of chlorhexidine or the derivative thereof, thereby sustaining the antibacterial effect for a long time.