Chlorinated Insect Growth Regulator for Selective Pest Control
Solution Overview
Problem
Current insecticides are ineffective in selectively targeting pests with minimal toxicity to vertebrates, and new insect growth regulators are in the early stages of development, necessitating the creation of more effective and safer alternatives.
Innovation Solution
The synthesis of ethyl {[N′-(3-chlorophenyl)-N-(2,4-dichlorobenzoyl)carbamimidoyl]sulfanyl}acetate, a unique insect growth regulator, which is confirmed through elemental and spectroscopic investigations, and its application as an insecticidal agent, demonstrated to be effective against Spodoptera littoralis with an LC50 of 211.4 mg/L, comparable to Diflubenzuron.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional insecticides are used to control pest populations, then insecticidal effectiveness is improved, but toxicity to vertebrates increases
Solution Approach 1:
The patent applies local quality by designing a compound with specific selective toxicity - the ethyl {[N′-(3-chlorophenyl)-N-(2,4-dichlorobenzoyl)carbamimidoyl]sulfanyl}acetate compound is engineered to target insect-specific physiological pathways (chitin synthesis inhibition) while minimizing interaction with vertebrate biological systems, achieving differential effectiveness based on the target organism's unique characteristics
Solution Approach 2:
The patent employs parameter changes by modifying the chemical structure parameters of traditional insect growth regulator scaffolds, specifically incorporating chlorophenyl and dichlorobenzoyl groups with a carbamimidoyl sulfanyl linkage, which alters the compound's biological activity profile to enhance insecticidal selectivity while reducing vertebrate toxicity compared to conventional insecticides
2Object-affected harmful factors
If new insect growth regulators are developed to reduce vertebrate toxicity, then safety to vertebrates is improved, but insecticidal effectiveness may be compromised
Solution Approach 1:
The patent resolves this contradiction through parameter changes by optimizing the chemical structure of the insect growth regulator - the specific arrangement of chlorinated aromatic groups with the carbamimidoyl sulfanyl acetate moiety tunes the compound's biological properties to achieve both high insecticidal activity (LC50 values demonstrating effectiveness) and reduced vertebrate toxicity
Solution Approach 2:
The patent applies composite materials principles by creating a hybrid molecular structure that combines features of traditional insect growth regulators with modified aromatic substituents, resulting in a compound that exhibits both the desired safety profile and maintained or enhanced insecticidal effectiveness through synergistic structural elements
3Adaptability or versatility
If selective organic components are used to target pests specifically, then selectivity towards pests is improved, but insecticidal potency may be reduced
Solution Approach 1:
The patent applies local quality by designing the compound to interact with insect-specific targets - the ethyl {[N′-(3-chlorophenyl)-N-(2,4-dichlorobenzoyl)carbamimidoyl]sulfanyl}acetate structure is optimized for binding to or interfering with insect chitin synthesis enzymes while having minimal affinity for vertebrate biological targets, achieving high selectivity without sacrificing potency within the target pest population
Solution Approach 2:
The patent employs copying by developing a compound that mimics the mode of action of established insect growth regulators (juvenile hormone analogs and chitin synthesis inhibitors) while incorporating selective structural features, effectively copying the successful biological mechanism of existing IGRs and enhancing their selectivity profile through targeted molecular design
Data Source
AI summary
A compound 2,4-dichloro-N-[(3-chlorophenyl)carbamothioyl]benzamide, its synthesis, and its use as an insecticidal agent.