Choline Borate Complex for Shrimp WSSV Control
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Solution Overview
Problem
Current methods for controlling White Spot Syndrome Virus (WSSV) and Vibrio parahaemolyticus infections in shrimp aquaculture are ineffective, leading to significant losses in the industry, as existing treatments lack broad-spectrum efficacy and are often impractical or expensive.
Innovation Solution
A compound formed by the complexation of boric acid or its derivatives with a quaternary ammonium compound, such as choline chloride, is used to create a pharmaceutical composition that can be administered to shrimp to treat or prevent pathogenic infections, including WSSV and Vibrio parahaemolyticus.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing treatments are used to control WSSV and Vibrio parahaemolyticus infections, then treatment is provided, but efficacy is insufficient and costs are high
Solution Approach 1:
The patent combines boric acid (or its derivatives) with quaternary ammonium compounds to form a composite antimicrobial agent. This composite structure leverages the synergistic effects of both components: boric acid provides broad-spectrum antiviral and antibacterial activity, while quaternary ammonium compounds enhance membrane disruption and pathogen penetration. The result is a treatment with superior efficacy against WSSV and Vibrio parahaemolyticus compared to single-agent therapies, while maintaining cost-effectiveness through the use of readily available raw materials and simple formulation processes.
2Adaptability or versatility
If broad-spectrum antiviral and antibacterial agents are needed, then existing treatments are applied, but they lack broad-spectrum efficacy
Solution Approach 1:
The boric acid-quaternary ammonium compound formulation is designed to perform multiple functions simultaneously: it acts as an antiviral agent against WSSV, an antibacterial agent against Vibrio parahaemolyticus, and a general immune modulator for shrimp. The boric acid component provides broad-spectrum activity against diverse pathogens through its ability to disrupt microbial metabolism and inhibit replication, while the quaternary ammonium moiety enhances membrane penetration and cytotoxicity against both viral and bacterial infections. This multi-functional design allows a single treatment to address multiple pathogen types effectively.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The choline/borate complex effectively increases the survival rate of shrimp challenged with WSSV and Vibrio parahaemolyticus, providing a cost-effective and practical solution for reducing disease impact in aquaculture, with no apparent toxicity at tested doses.
Implementation Method 1
A compound formed by the complexation of boric acid or its derivatives with a quaternary ammonium compound
Data Source
AI summary
The present document describes compounds resulting from the complexation of quaternary ammonium compounds with boric acid and/or its derivatives, and methods of making the same, and methods of using the same for the treatment of pathogenic infections.