Low Odor Choline Ellagate Salt Preparation via Inert Atmosphere
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Commercial preparations of choline ellagate and other choline salts often have an unpleasant amine odor due to impurities and degradation, affecting consumer acceptance and bioavailability.
Innovation Solution
A method involving a liquid suspension of ellagic acid and choline in methanol at a pH of 6.95 to 8, under reduced oxygen, followed by cooling and drying, to produce choline ellagate salts with higher purity and reduced odor, increasing solubility and bioavailability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If conventional methods are used to prepare choline ellagate salts, then the production process is simple, but the product has unpleasant amine odor and lower purity
Solution Approach 1:
The patent applies inert atmosphere by conducting the reaction under nitrogen or argon gas to prevent oxidation of choline and formation of odorous degradation products. The reaction vessel is purged with inert gas before and during the reaction to maintain an oxygen-free environment, thereby producing higher purity choline ellagate salt with minimal amine odor.
Solution Approach 2:
The patent changes key reaction parameters including maintaining pH between 6.95-8.0, controlling temperature between 20-40°C, and using specific molar ratios of choline to ellagic acid (1.05:1 to 1.2:1). These parameter optimizations prevent choline degradation and minimize odorous byproduct formation while ensuring complete reaction.
2Reliability
If conventional preparation methods are used, then the manufacturing process is straightforward, but the solubility and bioavailability of the product are reduced
Solution Approach 1:
The patent optimizes reaction parameters including pH control (6.95-8.0), temperature (20-40°C), and molar ratios (choline:ellagic acid = 1.05:1 to 1.2:1) to produce choline ellagate salt with enhanced solubility and bioavailability. These controlled conditions ensure complete reaction and high purity product that dissolves more readily in biological systems.
Solution Approach 2:
The patent employs continuous stirring throughout the reaction process to ensure complete mixing and reaction between choline and ellagic acid. The reaction is maintained under continuous inert gas flow and controlled temperature to ensure consistent product quality and maximum solubility without requiring complex post-processing steps.
3Stability of the object's composition
If conventional methods are used to produce choline salts, then production time is shorter, but the stability and degradation resistance of the product is lower
Solution Approach 1:
The patent conducts the entire reaction and workup process under inert atmosphere (nitrogen or argon) to prevent oxidation of choline and formation of degradation products. The inert gas protects the choline ellagate salt throughout synthesis, isolation, and storage, significantly enhancing product stability without requiring extended reaction times.
Solution Approach 2:
The patent prepares solutions of choline and ellagic acid separately under inert atmosphere before mixing, ensuring both starting materials are free from oxidation. The reaction vessel is purged with inert gas before adding reagents, and the entire process is maintained under positive pressure of inert gas to prevent degradation during the relatively short reaction time.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method results in choline ellagate salts with lower odor, higher stability, and increased bioavailability, enhancing absorption and metabolite production in subjects compared to conventional methods.
Implementation Method 1
cooling the liquid suspension of step (b) to 20 °C to -80 °C
Implementation Method 2
cooling the liquid suspension containing the choline ellagate salt(s) in the dark and protected from moisture and oxygen
Implementation Method 3
drying the isolated choline ellagate salt(s)
Data Source
Figure 1
Figure 2
AI summary
Methods of making low odor choline salts of an organic compound, for example, choline ellagate compound(s), and uses and formulations thereof.