Choline Succinate Composition for Metabolic Support
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Solution Overview
Problem
There is a lack of effective commercial choline-containing food products and dietary supplements that can simultaneously support and enhance both one-carbon (1C) and energy metabolisms, particularly in addressing metabolic stress and imbalanced 1C metabolism associated with aging and various diseases in humans and domestic animals.
Innovation Solution
A composition comprising choline and succinate in a 2:1 molar ratio, optionally with nicotinamide, vitamin B12, vitamin B6, vitamin B9, and docosahexaenoic acid (DHA), which is administered daily to support, enhance, or restore one-carbon metabolism, mitigate metabolic stress, and promote overall health and wellbeing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If choline supplementation is provided to support one-carbon metabolism, then methyl group availability is improved, but energy metabolism support is insufficient
Solution Approach 1:
The patent combines choline (supporting one-carbon metabolism) with succinate (supporting energy metabolism) in a specific molar ratio of 2:1 to 4:1. This merging of two different metabolic support agents into a single composition enables simultaneous support of both one-carbon and energy metabolisms, resolving the limitation of choline alone which only addresses methyl group availability.
Solution Approach 2:
The composition achieves multi-functionality by incorporating choline for one-carbon metabolism support and succinate for energy metabolism support (TCA cycle and electron transport chain). This universal composition can address multiple metabolic needs simultaneously, making it adaptable to various conditions including aging, metabolic stress, and disease states affecting both metabolic pathways.
2Reliability
If dietary supplements are developed to address metabolic stress and aging, then health benefits are improved, but lack of commercial products remains
Solution Approach 1:
The patent specifies precise molar ratios of choline to succinate (2:1 to 4:1) to optimize the synergistic effect on both one-carbon and energy metabolisms. This parameter optimization ensures reliable health benefits while the use of well-established nutrients (choline and succinate) simplifies manufacturing compared to novel compounds, facilitating commercial product development.
3Adaptability or versatility
If choline and succinate are combined in optimal molar ratio, then dual metabolism support is achieved, but formulation complexity increases
Solution Approach 1:
By merging choline and succinate into a single compositional unit with defined molar ratios, the patent simplifies the formulation process despite the complexity of supporting dual metabolisms. The specific ratio range (2:1 to 4:1) provides a practical formulation guideline that balances metabolic effectiveness with manufacturing simplicity, avoiding the need for complex delivery systems or multiple separate supplements.
Data Source
AI summary
The present invention relates to nutritional compositions for maintaining and enhancing one carbon (1C) metabolism. The compositions are useful for maintaining general body health, reducing physiological consequences of metabolic stress, enhancing anabolism in a growing body or in a body recovering from a disease or trauma, activating anabolic processes in the ageing body of a mammal, such as a human individual or domestic animal. The compositions comprise a combination of choline and succinate in the molar ratio 2:1.