Two-Dimensional Chromatogram Differential Analysis
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Solution Overview
Problem
Conventional data-processing software for comprehensive two-dimensional chromatographs lacks efficient functions for comparing multiple chromatograms with a large number of blobs, making it difficult for analysis operators to identify important or notable blobs and determine their correspondence.
Innovation Solution
A data processing device that creates two-dimensional chromatograms for compared samples, calculates differential chromatograms, detects blobs, extracts matching blobs, and highlights significant blobs on the chromatograms, allowing for efficient comparative analysis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If conventional data-processing software is used for comprehensive two-dimensional chromatographs, then basic chromatogram creation is possible, but efficient comparison functions for multiple chromatograms with large number of blobs are lacking
Solution Approach 1:
The patent segments the complex task of comparative analysis into distinct functional modules: chromatogram creation, blob detection, differential calculation, and result presentation. Each module handles a specific aspect of the analysis, making the overall complex process manageable and efficient.
Solution Approach 2:
The patent introduces an intermediary differential chromatogram that mediates between the original chromatograms and the final comparison results. This differential chromatogram serves as a bridge that highlights differences automatically, reducing the complexity of direct multi-chromatogram comparison.
2Measurement precision
If manual analysis of multiple chromatograms is performed, then detailed examination is possible, but identification of important blobs and determination of correspondence becomes difficult
Solution Approach 1:
The patent performs preliminary actions by automatically detecting blobs and calculating differential chromatograms before the analyst needs to interpret results. This preliminary processing identifies important features and prepares the data, saving time and improving accuracy in the subsequent analysis stage.
Solution Approach 2:
The system provides feedback through the differential chromatogram that highlights differences between samples. This visual feedback mechanism guides the analyst's attention to important blobs and their correspondences, improving identification accuracy while reducing the time required for manual examination.
3Loss of information
If all blobs are presented equally in chromatograms, then complete data is provided, but important or notable blobs cannot be distinguished
Solution Approach 1:
The patent applies local quality by differentiating the presentation of blobs based on their significance. The differential chromatogram provides local enhancement to regions with important differences, allowing complete data to be preserved while making important blobs visually distinguishable through differential signals.
Data Source
AI summary
A two-dimensional chromatogram creator creates a two-dimensional chromatogram based on data obtained for each of two samples. A chromatogram difference calculator creates a two-dimensional differential chromatogram showing the intensity difference between the two two-dimensional chromatograms. A blob detector detects blobs on each chromatogram. A matching-blob extractor compares the blobs located on the differential chromatogram with those located on each of the two other chromatograms, to extract blobs which can be considered to be located at the same temporal position. If there are two blobs extracted at the same temporal position on the two chromatograms, a normalized value of the intensity difference between the two blobs is calculated, and the line type of the boundary line for indicating the extracted blob on the display is chosen according to that value. Important blobs having significant intensity differences on the two chromatograms being compared can be automatically selected and presented to analysis operators.