Liquid Chromatograph Cost Performance Calculation
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing methods for reducing carryover in liquid chromatographs do not provide a straightforward way for users to estimate the cost effectiveness of using a cleaning solution, making it difficult for users to determine whether to introduce the cleaning solution.
Innovation Solution
A calculation method and an analysis device that calculate the cost performance of a cleaning solution by determining the period shortened and the profit gained when using a second cleaning solution instead of a first cleaning solution, based on analysis time, cleaning time, number of calibrations, samples analyzed, batches analyzed, and reanalysis rate.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If a cleaning solution is introduced to reduce carryover, then the productivity and analysis efficiency are improved, but the device complexity and operational complexity increase due to the need to evaluate and manage multiple cleaning solutions
Solution Approach 1:
The system automatically calculates and displays cost performance information by integrating with the liquid chromatograph's control unit, eliminating the need for manual calculation and reducing operational complexity while maintaining productivity improvements
Solution Approach 2:
A calculation unit acts as an intermediary between the cleaning solution selection and the user decision-making process, providing objective cost performance data that simplifies the evaluation of multiple cleaning solutions
2Productivity
If a cleaning solution is introduced to reduce carryover, then the productivity is improved by shortening cleaning time, but the loss of substance increases due to the consumption of additional cleaning solutions
Solution Approach 1:
The system evaluates different cleaning solutions based on their cost performance parameters, allowing users to select solutions that optimize the balance between cleaning efficiency and consumption costs by changing the evaluation criteria from purely time-based to cost-performance-based
3Measurement precision
If a cleaning solution is introduced to reduce carryover, then the measurement precision is improved by reducing contamination, but the difficulty of detecting and measuring increases due to the need to evaluate cost performance metrics
Solution Approach 1:
The calculation unit serves as an intermediary that automatically computes cost performance metrics, transforming complex evaluation parameters into simple display information that users can easily understand and use for decision-making
Solution Approach 2:
The system provides feedback by displaying cost performance information to users, enabling them to make informed decisions about cleaning solution selection based on quantitative data that balances measurement precision improvements against operational costs
Data Source
AI summary
A calculation method includes the steps of: calculating a third period shortened during a second period when a second cleaning solution is used in place of a first cleaning solution in a liquid chromatograph capable of batch analysis, based on an analysis time required for one-time analysis when the first cleaning solution is used, a cleaning time required for one-time cleaning, the number of calibrations per batch, the number of samples analyzed per batch, the number of batches analyzed during the first period, and a reanalysis rate that requires a reanalysis to confirm whether carryover has occurred; and calculating a second profit obtained during the second period when the second cleaning solution is used instead of the first cleaning solution, based on the third period, the number of samples analyzed per batch, the number of batches analyzed during the first period, and a first profit obtained per one-time analysis.