Chromatograph Data Processing Correcting Signal Saturation
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Conventional chromatograph systems face challenges in accurately analyzing samples with significantly varying component concentrations, as setting parameters for one component causes signal deformation or saturation of another, leading to inefficient multi-sample analysis or increased costs with dual detectors.
Innovation Solution
A data processing system for chromatographs that allows for single-analysis data processing using a single detector by creating a pre-correction chromatogram, designating alternative time and wavelength points, and applying a sensitivity factor to correct for signal deformation or saturation, enabling accurate analysis of both high and low-concentration components.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If the sample is prepared with a high level of overall concentration to correctly determine the peak areas of the low-concentration components, then the detection precision of low-concentration components is improved, but the signal of the high-concentration component becomes deformed or saturated
Solution Approach 1:
The patent segments the analysis process into multiple detection stages: first detecting the high-concentration principal component, then detecting the low-concentration impurity components. This segmentation allows each component to be detected under optimal concentration conditions, resolving the contradiction between detecting low-concentration components without saturating high-concentration components.
Solution Approach 2:
The patent applies preliminary action by first detecting and quantifying the high-concentration principal component before detecting the low-concentration impurity components. This sequential approach allows the system to handle components in order of concentration, preventing signal saturation of high-concentration components while ensuring accurate detection of low-concentration components.
2Measurement precision
If multiple samples with different concentrations are prepared and analyzed separately, then the measurement precision of all components is improved, but the analysis time increases significantly
Solution Approach 1:
The patent merges multiple detection tasks into a single analysis run. By implementing a detection system that can handle both high-concentration and low-concentration components in one measurement, it combines what would traditionally require multiple separate analyses, thereby maintaining measurement precision while significantly reducing analysis time.
Solution Approach 2:
The patent uses preliminary action by first detecting the high-concentration component and then using that information to guide the detection of low-concentration components. This sequential detection within a single analysis run allows the system to optimize detection parameters dynamically, achieving accurate measurement of all components without requiring multiple separate sample preparations.
3Measurement precision
If two detectors with different optical path lengths are used to analyze samples with varying concentrations, then the measurement precision of all components is improved, but the device complexity and cost increase
Solution Approach 1:
The patent applies parameter changes by dynamically adjusting the optical path length parameter during a single detection process. Instead of using multiple detectors with fixed optical path lengths, the system changes the optical path length parameter to match the concentration level of the component being detected, thereby achieving accurate measurement of both high- and low-concentration components with a single detector.
Solution Approach 2:
The patent implements universality by making a single detector capable of handling both high-concentration and low-concentration components through parameter adjustment. The detector is designed to function universally across different concentration ranges by dynamically changing its optical path length, eliminating the need for multiple specialized detectors and reducing device complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables accurate data processing of samples with varying concentrations using a single detector, correcting for noise and non-linearity issues, thus improving analysis efficiency and reducing costs.
Implementation Method 1
a detector for detecting the eluted components and for obtaining a spectrum within a predetermined wavelength range including a target wavelength
Data Source
AI summary
A system for creating a chromatogram based on a temporal change of a spectrum obtained within a predetermined wavelength range including a target wavelength, the system including a post-correction chromatogram display section for displaying a post-correction chromatogram obtained by multiplying a chromatogram at the designated wavelength by a sensitivity factor obtained by dividing the intensity of the designated-time spectrum at the target wavelength by the intensity of the designated-time spectrum at the designated wavelength, and for changing the display to a post-correction chromatogram corresponding to the latest values of the designated time point and the designated wavelength when one or both of the designated time point and the designated wavelength are changed.