Centrifugal Partition Chromatograph Extraction Cell Insert Design
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Solution Overview
Problem
Existing centrifugal partition chromatograph extraction cells are costly to manufacture, result in significant waste, and are inefficient due to the Coriolis force causing circular flow and remixing, which degrades separation efficiency.
Innovation Solution
The extraction cell is designed with a tubular body shaped extraction chamber and liquid inlet and outlet plugs, featuring an insert through which liquids can pass, reducing circular flow and improving droplet formation and mixing efficiency.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If extraction cells are milled from a single titanium alloy cylinder, then the device achieves structural integrity and sealing, but manufacturing cost increases and material waste is significant
Solution Approach 1:
The extraction cell is divided into multiple components: a body, a cover, and an insert. These parts can be manufactured separately using more efficient processes and then assembled, reducing material waste compared to milling a single monolithic titanium cylinder while maintaining structural integrity through precise mating surfaces and sealing mechanisms.
Solution Approach 2:
The insert is positioned within the extraction cell body and cover, creating a nested structure. This allows the insert to be manufactured separately and inserted into the assembled body, reducing overall material usage and manufacturing complexity while maintaining the structural integrity of the complete extraction cell.
2Reliability
If extraction cells are milled from titanium alloy, then sealing capability is achieved, but manufacturing expense increases
Solution Approach 1:
By segmenting the extraction cell into body, cover, and insert components, each part can be manufactured using cost-effective processes. The sealing capability is maintained through dedicated sealing surfaces and gasket locations designed into the segmented structure, avoiding the need for expensive monolithic titanium milling.
Solution Approach 2:
Instead of manufacturing the entire extraction cell from expensive titanium alloy, the invention applies titanium or titanium-like material properties only where structurally necessary (body and cover), while the insert can be made from different materials. Sealing surfaces are designed with local quality enhancements to ensure capability without requiring expensive materials throughout the entire structure.
3Ease of manufacture
If flat seals are used between covering plates, then assembly is simplified, but sealing performance degrades when exposed to organic solvents
Solution Approach 1:
The sealing solution uses different materials for different parts of the sealing system. The insert is made from materials resistant to organic solvents (such as PTFE, PEEK, or stainless steel), while the body and cover can use aluminum or stainless steel. This local application of solvent-resistant materials at the sealing interface maintains both assembly simplicity and sealing performance in the presence of organic solvents.
Solution Approach 2:
The extraction cell employs composite construction with the insert made from solvent-resistant materials (PTFE, PEEK, or stainless steel) while the body and cover can be aluminum or stainless steel. This composite approach ensures sealing performance is maintained when exposed to organic solvents while keeping the overall assembly simple and cost-effective.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This design reduces waste, lowers production costs, and enhances separation efficiency by minimizing the Coriolis force effect and improving phase contact interface.
Implementation Method 1
the mobile phase enters the cell containing the stationary phase through the inlet opening and breaks up into tiny droplets
Implementation Method 2
The resultant of the centrifugal force and the buoyancy will be exerted on the tiny droplets of the mobile phase, due to which the droplets will flow through the stationary phase
Implementation Method 3
The resultant of the centrifugal force and the buoyancy will be exerted on the tiny droplets of the mobile phase
Implementation Method 4
Coriolis force appears in the reference frame of the cells due to the rotation, as a result of which the path of the mobile phase is diverted
Data Source
Figure 1a~2b
Figure 3~5b
Figure 6a~7
AI summary
The object of the invention relates to an extraction cell for a centrifugal, partition chromatograph, which extraction cell contains an extraction chamber delimited by a cell wall and accommodates the liquid stationary phase, and it has a liquid inlet opening and a liquid outlet opening serving to let in and out the liquid mobile phase to be made to flow through the extraction cell. The essence of the extraction cell is that it contains an extraction chamber established as a tubular body, and a liquid inlet plug that includes a liquid inlet opening and a liquid outlet plug that includes a liquid outlet opening, that can be attached to the extraction chamber. An insert is included in the extraction cell chamber in order to overcome the effects of the Coriolis force on the mobile phase. The diameter of the passages of the insert is chosen dependant on the diameter of the droplets of the mobile phase. The object of the invention also relates to a centrifugal partition chromatograph containing such an extraction cell, and a ( method for producing such an extraction cell.