Liquid Chromatograph Flow-Path State Detection by Absorption Features
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Solution Overview
Problem
Existing methods for detecting abnormalities in a liquid chromatograph's flow path based on liquid sending pressure fluctuations are inadequate for identifying subtle issues that can affect analysis results.
Innovation Solution
A flow-path state output device that includes a feature acquirer to measure a sample with a known component and a state outputter to display flow-path state information based on measurement results, using a personal computer connected to a liquid chromatograph, allowing for the identification of flow-path states through graphical and determination-based outputs.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If liquid sending pressure fluctuation range is used to detect abnormalities, then liquid sending failure can be detected, but subtle abnormalities in the flow path that affect analysis results cannot be detected
Solution Approach 1:
The patent replaces the mechanical pressure-based detection system with an optical detection system. Instead of measuring pressure fluctuations mechanically, the system uses a detector to measure the absorption characteristics of the mobile phase at specific wavelengths, converting mechanical measurements to optical measurements to detect flow path abnormalities.
Solution Approach 2:
The patent changes the detection parameter from pressure fluctuation range to absorption characteristic values. By measuring the absorption of the mobile phase at multiple specific wavelengths and calculating absorption characteristic values, the system transforms the detection basis to identify flow path abnormalities that pressure fluctuation methods cannot detect.
2Measurement precision
If pressure fluctuation method is used, then liquid sending failures are detected, but flow path abnormalities with small pressure changes are missed
Solution Approach 1:
The patent substitutes mechanical pressure measurement with optical absorption measurement. The detector measures absorption characteristics at specific wavelengths, providing a more sensitive detection method that can identify flow path abnormalities even when pressure changes are minimal, thereby improving measurement precision without compromising analysis reliability.
Solution Approach 2:
The patent changes the measurement parameter from pressure to absorption characteristic values. By measuring absorption at multiple specific wavelengths and calculating derived values, the system achieves higher precision in detecting flow path abnormalities that would be missed by pressure fluctuation methods alone.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables the detection of flow-path states in a liquid chromatograph that are difficult to identify through pressure fluctuations, facilitating proactive management of potential abnormalities before they significantly impact analysis results.
Implementation Method 1
a detector that detects an absorption characteristic of the mobile phase at a specific wavelength
Data Source
AI summary
A computer that is a flow-path state output device of one embodiment is connected to a liquid chromatograph, and acquires a result of an analysis process executed in the liquid chromatograph. The computer includes a feature acquirer and a state outputter. The feature acquirer measures, using an analysis device, a sample containing a known component, and acquires a feature based on a measurement result. The state outputter, based on the feature, outputs a flow-path state of the liquid chromatograph to a display.