Multi-Correction Chromatograph Analysis Using Grouped Surrogate Standards
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Solution Overview
Problem
In simultaneous multicomponent analysis using chromatographs, preparing individual internal or surrogate standard substances for each object substance is impractical, especially when dealing with a large number of compounds having similar chemical and physical properties, as it is difficult to accurately correct for losses during pretreatment and analysis without such substances.
Innovation Solution
A multi-correction analysis method that groups object substances based on changes in measured values obtained under different analysis conditions, determining a surrogate substance for each group and using it as an internal standard to correct measured values across the group.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If individual internal standard substances are prepared for each object substance, then measurement precision is improved, but device complexity and analysis time increase significantly
Solution Approach 1:
The patent segments the large number of object substances into multiple groups based on their physical and chemical properties. Each group is assigned a representative internal standard substance, reducing the need for individual standards while maintaining correction accuracy within each property-based segment.
Solution Approach 2:
The patent creates internal standard substances that can serve multiple functions across different object substances within the same group. A single internal standard substance corrects measurement errors for multiple compounds with similar properties, eliminating the need for unique standards for each compound.
2Measurement precision
If individual surrogate substances are used for each object substance, then correction accuracy is improved, but productivity decreases due to extensive preparation work
Solution Approach 1:
The patent merges the correction function for multiple object substances into a single internal standard substance for each group. By combining several correction tasks into one standard substance, the preparation workload is reduced while maintaining adequate correction accuracy for all substances in the group.
Solution Approach 2:
The patent changes the selection criterion from individual substance matching to group-based property matching. By selecting internal standard substances based on group characteristics rather than individual compound properties, the preparation process becomes more efficient while maintaining correction effectiveness.
3Productivity
If a single internal standard substance is used for all object substances, then analysis efficiency is improved, but measurement precision deteriorates due to property differences
Solution Approach 1:
The patent divides all object substances into multiple groups based on their physical and chemical properties. Each group receives its own internal standard substance, ensuring that the standard is chemically similar to the substances it corrects. This segmentation maintains precision while avoiding the inefficiency of using individual standards for every substance.
Solution Approach 2:
The patent applies different internal standard substances to different groups of object substances based on their local chemical and physical properties. Each group receives a standard substance tailored to its specific property profile, ensuring locally optimized correction accuracy rather than a one-size-fits-all approach.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables accurate correction of measured values for a large number of object substances with similar properties without the need for individual standard substances, improving analysis efficiency and accuracy by considering influences from pretreatment and analysis processes.
Implementation Method 1
When a measured value of a compound in a sample is corrected using a chromatograph such as a gas chromatograph (GC) or a liquid chromatograph (LC)... not only temporal component separation by a chromatograph but also component separation according to a mass-to-charge ratio
Implementation Method 2
component separation according to a mass-to-charge ratio using a gas chromatograph mass spectrometer (GC/MS) or a liquid chromatograph mass spectrometer (LC/MS)
Data Source
AI summary
A multi-correction analysis method for correcting a result of analyzing a large number of object substances contained in a sample using a chromatograph, includes: grouping at least a part of a large number of object substances possibly contained in a sample to be analyzed into groups based on changes in the measured values of the part of the object substances obtained by performing chromatographic analysis of the sample under different analysis conditions, and determining a surrogate substance for each of the groups; and adding the surrogate substance to the sample as an internal standard substance common to the object substances contained in each group, and correcting a measured value of each of the large number of object substances obtained from a result of chromatographic analysis of the sample with a measured value of the internal standard substance corresponding to the group to which the object substance belongs.