Chromatograph Data Processing Using Multi-Wavelength Sensitivity Coefficients
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Solution Overview
Problem
Chromatograph data processing systems face limitations in accurately determining the concentration ratio of components with significantly different concentrations due to signal distortion and saturation, requiring multiple analyses and corrections for accurate measurement.
Innovation Solution
A data processing system for chromatographs that uses a sensitivity coefficient to analyze samples at multiple wavelengths, allowing for the calculation of concentration ratios between components within a broad absorbance range using a single detector and analysis, by measuring peak areas and heights at different wavelengths and applying correction factors.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If parameters are set to correctly detect the lowest-concentration component (impurity), then detection sensitivity for low-concentration components is improved, but the signal corresponding to the highest-concentration component (principal component) becomes distorted or saturated
Solution Approach 1:
The patent introduces a wavelength dimension to solve the concentration range problem. By measuring absorbance at multiple wavelengths (peak wavelength and non-peak wavelength) and using the ratio of these measurements, the system can determine concentration ratios across a broad absorbance range (0.1-2.0 or wider) without signal saturation or excessive noise, effectively adding a dimensional approach to overcome the dynamic range limitation.
2Manufacturing precision
If parameters are set to correctly detect the highest-concentration component (principal component), then signal accuracy for high-concentration components is improved, but the lowest-concentration component (impurity) becomes obscured by noises
Solution Approach 1:
The patent uses multi-wavelength measurement to simultaneously capture information about both high-concentration and low-concentration components. The ratio of absorbance at peak wavelength to non-peak wavelength allows accurate determination of concentration ratios without the need to compromise between detecting high-concentration or low-concentration components, eliminating the need for multiple separate measurements.
3Measurement precision
If multiple analyses with different sample concentrations are performed to accurately determine concentration ratios, then measurement accuracy is improved, but analysis time increases
Solution Approach 1:
The patent merges multiple measurement functions into a single analysis run. By simultaneously measuring absorbance at multiple wavelengths and calculating concentration ratios from the ratio of peak to non-peak absorbance, the system achieves accurate concentration ratio determination in a single analysis, eliminating the need for separate measurements of diluted samples and combining results through correction calculations.
4Measurement precision
If two cells with different optical path lengths are used in two detectors to measure concentration ratios, then measurement accuracy for components with different concentrations is improved, but device complexity increases
Solution Approach 1:
The patent makes a single detector perform multiple functions by measuring at multiple wavelengths. Instead of requiring two detectors with different optical path lengths, the system uses one detector to measure both peak and non-peak wavelength absorbance, with the wavelength ratio serving as the correction factor that would otherwise require different optical path lengths, thereby simplifying the device configuration.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables the determination of concentration ratios over a broad absorbance range with a single analysis and single detector, reducing analysis time and system complexity while improving accuracy.
Implementation Method 1
a spectroscopic analyzer for spectroscopically analyzing a sample exiting from a component-separating column and for measuring an intensity at a second wavelength λ2 of a spectrum of a first component and an intensity at a wavelength λ3 of a spectrum of a second component
Data Source
AI summary
A data processing system including a sensitivity coefficient holder for holding a value R of a sensitivity coefficient for a wavelength λ1 belonging to one peak in a spectrum of a first component and a second wavelength λ2 belonging to the same peak and having a lower intensity than λ1, the value R defined using the ratio of the peak areas or similar information of two chromatograms respectively obtained at the two wavelengths; a chromatographic detector for spectroscopically analyzing sample components exiting from a component-separating column and for measuring an intensity at the second wavelength λ2 of the spectrum of the first component and an intensity at a wavelength λ3 of a spectrum of a second component at each point in time; and a concentration ratio calculator for calculating the ratio of concentration between the first component and the second component.