Liquid Chromatograph Purge Automation via Macro Programs
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Solution Overview
Problem
Current liquid chromatograph analysis apparatuses face challenges in automating the purge operation due to limitations in flow path configurations, requiring manual intervention and skilled user knowledge for setting purging conditions, especially when dealing with ionic compounds and miscible liquids, which can lead to blockages and corrosion.
Innovation Solution
A liquid chromatograph analysis apparatus with a macro program creation and execution system that allows for automated purge operations by defining operating orders and condition values for flow paths, pressure control, and solvent mixing ratios, using a solvent database to determine optimal conditions and a user-friendly wizard for inputting information.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Extent of automation
If a dedicated hardware system is used to manage flow path length and tube diameter for automated purging, then automation capability is improved, but flow path configuration flexibility deteriorates
Solution Approach 1:
The patent implements automated purging by dynamically adjusting flow rate parameters based on detected flow path conditions. The system monitors pressure and flow rate parameters, and automatically modifies purging parameters to match the actual flow path configuration, eliminating the need for dedicated hardware while maintaining automation capability and flexibility.
Solution Approach 2:
The system performs self-diagnosis by detecting flow path conditions through pressure and flow rate sensors, then automatically configures purging operations without requiring pre-programmed hardware settings. The control unit autonomously adjusts purging parameters based on real-time measurements, enabling the system to adapt to various flow path configurations.
2Extent of automation
If purge operation is performed as part of analysis using analysis files, then automation is improved, but operational flexibility deteriorates
Solution Approach 1:
The patent separates purging operations from analysis operations by providing independent purging control. The system can execute purging either as part of automated analysis sequences or as instantaneous standalone operations through dedicated purging commands, allowing flexible operational modes without compromising either automation or immediate response capability.
Solution Approach 2:
The system dynamically switches between different operational modes - integrated purging during analysis sequences and instantaneous purging on demand. The control unit can adaptively select the appropriate purging mode based on user commands and analysis state, providing both automated batch processing and immediate responsive purging capabilities.
3Ease of manufacture
If buffer solution is replaced directly with nonionic liquid, then storage preparation is improved, but precipitation risk increases
Solution Approach 1:
The patent introduces an intermediary purging step using a non-buffered liquid with intermediate properties before final replacement with the nonionic storage liquid. This intermediary liquid serves as a transition medium that prevents direct contact between buffer solution and nonionic liquid, thereby preventing precipitation of ionic compounds while still achieving the desired storage preparation.
Solution Approach 2:
The system performs preliminary purging operations to remove buffer solution completely before introducing the nonionic storage liquid. By executing preliminary purging steps that flush the flow path thoroughly, the system eliminates the risk of precipitation when the final nonionic liquid is introduced, while maintaining simple storage preparation procedures.
4Reliability
If multiple liquids are used for purging ionic compounds, then precipitation prevention is improved, but operational complexity increases
Solution Approach 1:
The patent manages multi-liquid purging by automatically adjusting flow rate, pressure, and sequence parameters based on the specific liquid combinations and ionic compound characteristics. The control unit monitors purging progress and dynamically modifies operational parameters to optimize the multi-liquid sequence, preventing precipitation while maintaining manageable operational complexity through automated parameter management.
Data Source
AI summary
A liquid chromatograph analysis apparatus includes: a macro storing section for storing a macro program having various commands related to a purge operation; a macro executing section for reading the macro program and analyzing and executing the program thus read; and a solvent database in which information on properties of solvents are stored. Based on information input by a user and the information stored in the solvent database, an optimum condition value is determined. Thus, a macro creating function for creating the macro program having operation commands based on the optimum condition value is provided. Further, the macro program can be instantly executed by operating a switch attached to the apparatus body.