Chromatographic Data Processing Device Dynamic Range Adjustment
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Solution Overview
Problem
Chromatographic data processing devices rely on operator experience and intuition to adjust sample concentrations, leading to inaccurate results when signal strengths exceed hardware limits or detector nonlinearity issues, particularly in UV-visible spectrophotometers, requiring multiple assays to find the optimal concentration range.
Innovation Solution
A data processing device that calculates and adjusts the concentration of target components by setting analysis parameters, determining signal strength ratios, and applying correction values to ensure peak strengths fall within the dynamic range, automating the preprocessing and analysis process.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If manual sample concentration adjustment is performed based on operator experience, then the analysis can be performed, but the reliability of detection results deteriorates when signal strength exceeds hardware limits or detector nonlinearity occurs
Solution Approach 1:
The system automatically determines the appropriate sample concentration by having the chromatographic data processing device calculate the concentration adjustment coefficient based on the measured peak strength and pre-stored dynamic range information, eliminating the need for operator experience and intuition in concentration selection
Solution Approach 2:
The dynamic range information is pre-stored in the storage unit before analysis, and the system performs preliminary calculation of the concentration adjustment coefficient before actual measurement, allowing the device to automatically adjust sample concentration and avoid signal saturation or nonlinearity issues
2Measurement precision
If multiple assays with different dilution ratios are performed to find optimal concentration, then accurate results can be obtained, but the productivity deteriorates due to repeated measurements
Solution Approach 1:
The system performs preliminary calculation of the concentration adjustment coefficient before actual measurement by using the measured peak strength and pre-stored dynamic range information, determining the optimal sample concentration in advance to avoid the need for multiple repeated assays with different dilution ratios
Solution Approach 2:
The system uses feedback from the measured peak strength to automatically adjust the sample concentration by calculating the concentration adjustment coefficient, which is then applied to determine the appropriate dilution or concentration factor for maintaining peak strength within the dynamic range
3Device complexity
If sample concentration is not adjusted, then the analysis process is simple, but the measurement precision deteriorates when peak strength exceeds the dynamic range
Solution Approach 1:
The system automatically performs concentration adjustment by calculating the concentration adjustment coefficient based on measured peak strength and pre-stored dynamic range information, making the device self-regulating and eliminating the need for manual operator intervention to maintain measurement precision within the dynamic range
Data Source
AI summary
A chromatographic data processing device, data processing method, and chromatographic analysis system. When chromatographic analysis is performed, the data processing device obtains 3D data for time, wavelength, and strength from the PDA, and finds the assay value for the target component in the liquid sample by processing said data. If the peak top strength of the target component falls outside of the dynamic range, a dilution ratio for the liquid sample is determined by calculating the peak top strength of the target component using the ratio of the strength at the peak top wavelength on the spectrum for each point in time belonging to the peak to the strength of a separate wavelength.