Chromatographic Data Processor 3D Graph Optimization
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Solution Overview
Problem
High Performance Liquid Chromatography (HPLC) users face challenges in quantitatively analyzing the relationship between pressure drop, hold-up time, and the number of theoretical plates, making it difficult to optimize separation conditions and calculate these parameters effectively.
Innovation Solution
A chromatographic data system processing apparatus that introduces a new dimensionless index for the slope of a three-dimensional space representing column length, linear velocity, and the number of theoretical plates, allowing for easy analysis of separation conditions through a three-dimensional graph transformation and the application of standardization based on optimal linear velocity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If users manually manipulate flow rate to search for separation conditions, then separation performance can be optimized, but the analysis time and complexity increase significantly
Solution Approach 1:
The system pre-calculates and stores the relationship between flow rate, pressure drop, hold-up time, and number of theoretical plates in a three-dimensional graph before actual analysis. This preliminary preparation allows users to directly query optimal conditions without time-consuming manual experiments during the analysis phase.
Solution Approach 2:
The patent introduces a data processor as an intermediary that automatically calculates and transforms chromatographic parameters (pressure drop, hold-up time, number of theoretical plates) based on flow rate and column length. This mediator eliminates the need for users to perform complex manual calculations and experiments, directly providing optimized separation conditions.
2Measurement precision
If users directly measure pressure drop and hold-up time to calculate number of theoretical plates, then quantitative analysis can be achieved, but the measurement and calculation complexity increases
Solution Approach 1:
The system automatically performs self-calibration and self-calculation by using the measured flow rate and column length to compute pressure drop, hold-up time, and number of theoretical plates through pre-established relationships. This self-service mechanism eliminates the need for complex manual measurement and calculation procedures.
Solution Approach 2:
The patent replaces manual mechanical measurement and calculation methods with an automated data processing system that uses computational algorithms to transform basic parameters (flow rate, column length) into derived parameters (pressure drop, hold-up time, number of theoretical plates), significantly reducing measurement and calculation complexity.
3Measurement precision
If traditional two-dimensional graphs are used to represent separation conditions, then simplicity is maintained, but the ability to quantitatively analyze the relationship between pressure drop, hold-up time, and number of theoretical plates is insufficient
Solution Approach 1:
The patent transitions from traditional two-dimensional graphs to a three-dimensional graphical representation that simultaneously displays the relationships between flow rate, pressure drop, hold-up time, and number of theoretical plates. This dimensional expansion allows users to quantitatively analyze the interrelationships between these parameters while maintaining visual intuitiveness through the data processor's transformation capabilities.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables users to quantitatively grasp the performance obtained and efficiently search for optimal separation conditions by transforming representations and applying Pressure-Application Efficiency indices, ensuring high-speed analysis with consistent separation performance.
Implementation Method 1
a liquid chromatography apparatus, includes: a liquid feeder configured to feed a mobile phase; a sample injector configured to inject a sample into a mobile phase flowing path into which the mobile phase is fed; a column configured to separate the injected sample into a plurality of analytes; and a detector configured to detect the separated analytes
Data Source
AI summary
A chromatographic data system processing apparatus includes a liquid feeder, a sample injector, a column that separates samples, a detector, a controller that processes a detected result of the detector, and a data processor that examines and sets operations of the liquid feeder, the column and the detector, and a measurement condition. The data processor generates a three-dimensional graph having three axes related to a pressure, a time, and a number of theoretical plates based on data or variables indicating a relationship between the number of theoretical plates and a flow rate, and data or variables indicating a relationship between the pressure and the flow rate. The chromatographic data system processing apparatus can easily obtain a separation condition for obtaining performance from a three-dimensional graph including a pressure drop, a hold-up time and a number of theoretical plates.