Chromatographic Data System Peak Identification via Dynamic Table Adjustment
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Solution Overview
Problem
Chromatographic analysis methods fail to accurately identify peaks in unknown samples due to variations in measurement conditions, such as changes in retention time caused by device issues or chemical characteristics, leading to potential misidentification of peaks.
Innovation Solution
A chromatographic data system processing apparatus that adjusts the allowable width of the standard sample time table to accommodate variations in peak retention time, allowing for simultaneous identification of multiple peaks by altering the standard sample time table and setting a measurement sample time table based on actual retention times, thereby improving identification accuracy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If the standard sample time table is fixed with predetermined retention times and allowable widths, then the identification process is simple and fast, but identification accuracy deteriorates when retention times vary due to measurement condition changes
Solution Approach 1:
The patent applies dynamics by making the time table adjustable rather than fixed. The standard sample time table can be dynamically altered by extending allowable widths when peak number mismatches occur, and the time table can be regenerated from actual measurement data, enabling the system to adapt to varying retention times while maintaining efficient identification processes
Solution Approach 2:
The patent changes parameters by modifying the allowable width parameter in the time table based on measurement results. When the number of identified peaks does not match the expected peak number, the system extends the allowable width parameter to accommodate retention time variations, thereby improving identification accuracy without fundamentally changing the identification methodology
2Measurement precision
If the allowable width in the standard sample time table is extended to accommodate retention time variations, then identification accuracy improves, but the risk of identifying adjacent peaks increases
Solution Approach 1:
The patent implements feedback by using the peak number comparison result to control time table alterations. The system compares the number of actually measured peaks with the specified peak number, and only extends allowable widths when a mismatch is detected, thereby adaptively improving accuracy without unnecessarily increasing misidentification risk
Solution Approach 2:
The patent applies local quality by selectively extending allowable widths only for specific components where peak number mismatches occur, rather than uniformly expanding all time windows. This targeted approach improves identification accuracy for problematic peaks while maintaining stricter criteria for other peaks, reducing overall misidentification risk
3Productivity
If multiple peaks are identified simultaneously using a single time table, then processing efficiency improves, but identification accuracy may deteriorate compared to sequential peak identification
Solution Approach 1:
The patent applies segmentation by dividing the identification process into iterative cycles. Each cycle identifies a subset of peaks using the current time table, compares the identified peak number with expected values, and alters the time table accordingly. This segmented approach maintains processing efficiency through batch identification while improving accuracy through iterative refinement
Solution Approach 2:
The patent ensures continuity by maintaining the time table as a living data structure that is continuously refined across measurement cycles. Rather than performing discrete sequential identifications, the system continuously improves the time table based on accumulated measurement data, enabling simultaneous peak identification to achieve accuracy comparable to sequential methods
Data Source
AI summary
A chromatographic data system processing apparatus includes a standard sample time table for prestoring a first retention time and a first allowable width of each peak of specific components of a standard sample, a determination unit for determining whether a number of peaks coincides with a specified number when a peak cannot be identified, an alteration unit for altering the standard sample time table by increasing the first allowable width of a specific component to an altered allowable width, an identification unit for identifying the peaks based on the altered standard sample time table when all peaks fall within a range of the altered allowable width, and a setting unit for acquiring an actually-measured retention time of the peaks, and setting a measurement sample time table based on the actually-measured retention time and a second allowable width when the peaks are identified based on the altered standard sample time table.