Chromatographic Test Device Liquid Leakage Control
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Solution Overview
Problem
Chromatography techniques face challenges with liquid leakage from containers, leading to contamination and false-positive results due to negative pressure and inefficient liquid contact with the chromatography support, especially when the container and support are misaligned or require significant force to incise, and surfaces with high water contact angles hinder liquid wettability and absorption.
Innovation Solution
A test device with a housing that supports a container and a blade for incising, where the container is guided to form an incision surrounding a gas phase, reducing negative pressure and facilitating efficient liquid leakage, and the chromatography support has a perforation/incision target part and surfaces with a water contact angle of 90 degrees or smaller for improved wettability and absorption.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a part of the container is broken to leak liquid without using an instrument, then liquid can contact the chromatography support without contamination risk, but negative pressure is created inside the container causing the liquid to stop leaking
Solution Approach 1:
The container is segmented into two functional parts: a liquid-tight section that maintains pressure and a perforated section that allows controlled liquid release. The perforation part includes multiple small holes distributed across its surface, enabling continuous liquid leakage while preventing complete vacuum formation that would stop the flow.
Solution Approach 2:
The perforation part acts as a porous structure with multiple small openings distributed across its surface. This porous design allows liquid to leak through continuously while maintaining pressure balance, preventing the complete vacuum effect that would occur with a single large opening or complete container breakage.
2Ease of manufacture
If the container and chromatography support are pushed together to perforate or incise them, then liquid can leak and contact the support, but great force is required due to resistance from the chromatography support
Solution Approach 1:
The chromatography support is pre-equipped with a reception groove and a protrusion that aligns with the container's positioning structure. This preliminary arrangement ensures that when the container is inserted and perforated, the liquid leaks directly into the groove, eliminating the need for additional force to position the support correctly during the incision process.
Solution Approach 2:
The reception groove acts as an intermediary structure between the container and the chromatography support. It receives the liquid directly from the container's perforation point, facilitating the transfer of liquid without requiring the container to be pushed forcefully against the support surface.
3Quantity of substance
If the container is incised to leak liquid, then liquid can contact the chromatography support, but the incision may not surround the gas phase properly causing incomplete liquid release
Solution Approach 1:
The container is designed with a perforation part that includes multiple holes distributed across its surface, and the chromatography support is pre-equipped with a reception groove. This preliminary arrangement ensures that when the container is inserted, the liquid leaks directly into the groove without requiring precise manual positioning during the incision process.
Solution Approach 2:
The device structure itself guides the container into the correct position through the interaction between the container's positioning structure and the chromatography support's reception groove. This self-alignment mechanism eliminates the need for external tools or manual adjustment to achieve proper incision positioning.
4Ease of manufacture
If surfaces with high water contact angle are used, then liquid leakage can occur, but liquid wettability and absorption are hindered
Solution Approach 1:
The surface properties of the chromatography support are modified to have a water contact angle of 90 degrees or smaller, changing the surface energy parameters to be more hydrophilic. This parameter change enables the liquid to wet the surface effectively and be absorbed by the chromatography support, improving both leakage control and absorption efficiency simultaneously.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device ensures efficient liquid leakage and contact with the chromatography support, reducing contamination risks and stabilizing testing conditions by minimizing negative pressure and enhancing liquid absorption.
Implementation Method 1
a blade with an edge provided thereon that incises the container supported by the supporting part to leak a liquid from the container
Implementation Method 2
the liquid comes into contact with the chromatography support... enhancing liquid absorption
Implementation Method 3
chromatography support with a nucleic acid immobilized thereon to develop, capture, and detect a detection target
Data Source
AI summary
A test device is provided that can comprise: a housing accommodating a chromatography support, wherein the housing comprises: a supporting part that supports a container accommodating a liquid used for chromatography. A method is provided for performing chromatography using the test device.