Liquid Chromatography Analysis Assistance Device Design Space Estimation
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Solution Overview
Problem
Existing analysis devices struggle to provide users with comprehensive information for optimizing analysis conditions, leading to suboptimal analysis results.
Innovation Solution
An analysis assistance device that includes an estimator to calculate the distribution of measurement quality index data based on various analysis conditions and measurement data, and a measurement quality index outputter that displays a design space where the measurement quality index exceeds a threshold value, with the ability to enlarge this space by cutting off non-relevant regions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Loss of information
If the user manually searches for optimal analysis conditions through method scouting, then the analysis device can provide basic unexamined condition suggestions, but the user cannot obtain comprehensive information for optimizing analysis conditions
Solution Approach 1:
The patent introduces an analysis assistance device as an intermediary between the user and the analysis device. This intermediary automatically performs method scouting, estimates measurement quality index distributions, and generates design space information, thereby compensating for the insufficient information provision while reducing the operational burden on the user.
Solution Approach 2:
The analysis assistance device enables the system to perform method scouting and optimization automatically without requiring extensive manual user intervention. The device independently executes experiments, analyzes results, estimates distributions, and generates optimization recommendations, making the system self-sufficient in providing comprehensive optimization information.
2Measurement precision
If the analysis device provides detailed distribution information of measurement quality index, then the user can optimize analysis conditions better, but the complexity of the analysis device increases
Solution Approach 1:
The patent creates a virtual model (design space) that copies and represents the complex relationship between analysis conditions and measurement quality. Instead of making the physical device more complex, it generates a simplified graphical representation that captures the essential optimization information, allowing users to interact with the copied model rather than the complex underlying system.
Solution Approach 2:
The patent replaces complex mechanical/manual method scouting processes with automated computational estimation and graphical display systems. The analysis assistance device uses software-based distribution estimation and automated experiment execution, substituting manual mechanical operations with electronic computation and automated control systems.
3Loss of information
If the user examines the entire distribution region of measurement quality index data, then comprehensive optimization information is available, but the user cannot easily identify the effective design space region
Solution Approach 1:
The patent extracts the design space region from the entire distribution region by applying a threshold to the measurement quality index. The design space extraction unit identifies and separates the effective region where the measurement quality index meets or exceeds the threshold, extracting only the relevant portion from the complete distribution data for focused user examination.
Solution Approach 2:
The patent uses visual differentiation (analogous to color changes) to distinguish the design space region from the rest of the distribution region. By graphically highlighting or differentiating the region where the measurement quality index meets the threshold, the system makes the effective area visually distinct and easily identifiable among the complete distribution data.
Data Source
AI summary
An analysis assistance device includes an estimator that estimates distribution of measurement quality index data using a plurality of analysis condition data to be provided to an analysis device and a plurality of measurement data obtained in the analysis device based on the plurality of analysis condition data, and a measurement quality index outputter that outputs for display a region where the measurement quality index data is not less than a predetermined threshold value as a design space, and the measurement quality index outputter outputs the region of the design space in an enlarged manner by cutting off at least part of a region other than the design space in a distribution region of the measurement quality index data.