Chromatography Audit Log Correlation System
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Solution Overview
Problem
Current chromatography systems face challenges in maintaining auditable logs across various components and steps of analysis, leading to tedious and labor-intensive cross-referencing of events across multiple logs, which can impact the validity of analysis and require additional security measures for method changes.
Innovation Solution
Implementing a scientific instrument support system with three logical components: one to obtain and log chromatography data, another to analyze and log data analysis events, and a third to identify and link events across audit logs, providing a user interface for viewing linked events and enforcing second-eye reviews for method changes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If multiple separate audit logs are maintained for different chromatography components and steps, then comprehensive audit coverage is achieved, but cross-referencing events becomes tedious and labor-intensive
Solution Approach 1:
The patent merges multiple separate audit logs into a single consolidated audit log that automatically correlates events from different chromatography components and steps. This consolidation maintains comprehensive audit coverage while eliminating the manual cross-referencing effort required when using separate logs, as all events are now presented in one unified view with automatic linking.
2Loss of information
If manual cross-referencing of audit logs is performed, then event correlation is achieved, but time consumption and labor intensity increase
Solution Approach 1:
The system implements automated event correlation that performs the cross-referencing function without human intervention. The audit log system automatically links related events from different chromatography components and steps, eliminating the need for manual cross-referencing and significantly reducing the time required to correlate events while maintaining complete event correlation.
3Productivity
If method changes are allowed without review, then operational efficiency is improved, but security and validity of analysis are compromised
Solution Approach 1:
The patent implements a feedback mechanism where method changes trigger an automated review process. When a method change is detected in the audit log, the system flags it for review and prevents implementation until approved, ensuring that productivity is maintained through streamlined processes while reliability is preserved through mandatory review feedback loops.
4Reliability
If comprehensive audit logging is implemented across all chromatography components, then complete traceability is achieved, but system complexity increases
Solution Approach 1:
The patent implements a universal audit logging system that serves multiple chromatography components and steps through a single multi-functional platform. This universal system maintains complete traceability across all components while reducing overall system complexity by eliminating the need for separate logging systems for each component, as one system performs all logging functions.
Data Source
AI summary
Disclosed herein are scientific instrument support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, a scientific instrument support apparatus includes a first logic to obtain chromatographic data sets from a chromatographic system; a second logic to perform a first analysis of the one or more chromatographic data sets to generate a first result perform a second analysis of the one or more chromatographic data sets to generate a second result; and a third logic to identify differences between the first result and the second result; provide a user interface configured to indicate the data sets where the second result differs from the first result; and display one or more chromatograms representative of the indicated data sets and visually identifying features on the chromatograms where the differences occur.