Chromatography Carrier Crosslinked Structure Antifouling

The patent uses a composite polymer structure combining hydrophilic units (for antifouling properties) with crosslinked units containing -C(=O)-NH- groups (for mechanical strength). This composite approach allows simultaneous achievement of both antifouling performance and pressure/shatter resistance that cannot be obtained with single-material systems.

The patent modifies the chemical structure parameters of the polymer by introducing specific crosslinked units with -C(=O)-NH- groups at controlled concentrations (5-50 mmol/g). This parameter change enables the polymer network to achieve both hydrophilicity for antifouling and crosslinking density for mechanical strength.

The patent creates a composite polymer system where hydrophilic units provide antifouling properties while crosslinked units with -C(=O)-NH- groups provide pressure resistance. The synergistic combination resolves the contradiction between these two opposing requirements.

The patent applies local quality by concentrating the crosslinked -C(=O)-NH- units at specific locations within the polymer network while maintaining hydrophilic regions elsewhere. This localized differentiation allows different regions to fulfill different functions optimally.

The patent introduces a crosslinked structure with -C(=O)-NH- groups that acts as a preventive reinforcement before deformation occurs. This crosslinked network provides beforehand cushioning against crushing and plastic deformation, allowing the carrier to withstand high flow rates during operation and maintain reusability.

The patent changes the mechanical parameters of the carrier by controlling the crosslinking degree through -C(=O)-NH- unit content (5-50 mmol/g). This parameter optimization enables the carrier to sustain high linear flow rates required for productivity while preventing deformation that would compromise reliability and reusability.