Handling Device for Chromatography Column Maintenance

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Solution Overview

Problem

Current maintenance methods for industrial-scale chromatography columns pose safety risks to operators due to the need for heavy lifting and manual handling of components, which can weigh over 100 kg, and require working under suspended loads, leading to potential injury and exposure to particulate matter.

Innovation Solution

A method and handling device that allow for the safe manipulation and transportation of heavy column components using a cart with extendable arms and a drive system, enabling the removal and reinstallation of bed supports and distributors without tilting them significantly, thus reducing operator exposure and facilitating mechanical handling.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of repair

If heavy lifting equipment such as cranes or hoists is used to lift column assemblies and components, then the ability to perform maintenance on internal components is improved, but operator safety deteriorates due to the risk of injury from working under suspended loads and exposure to particulate matter

Engineering Contradiction:
Improvemaintenance accessVSAvoidoperator safety
Core Design Contradiction:
Ease of repairVSObject-affected harmful factors

Solution Approach 1:

The invention extracts the bed support and distributor components from the column assembly, allowing them to be removed and placed on a separate support surface. This eliminates the need to work under suspended loads while maintaining access to internal components for maintenance, directly resolving the safety contradiction.

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The invention introduces an intermediary support surface or table that receives and supports the bed support and distributor components after removal from the column. This intermediary structure allows operators to work on components at a safe, accessible height rather than under suspended loads, while the column assembly can be independently supported.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Device complexity

If manual handling methods are used to remove and reinsert heavy bed supports weighing over 100 kg, then equipment complexity is reduced, but operator safety deteriorates due to physical injury risks

Engineering Contradiction:
Improvehandling equipmentVSAvoidoperator safety
Core Design Contradiction:
Device complexityVSObject-affected harmful factors

Solution Approach 1:

The invention enables the bed support and distributor to support themselves on a separate support surface after removal from the column. This self-service approach allows heavy components to be safely positioned and maintained without requiring complex mechanical lifting equipment, reducing both device complexity and safety risks.

Inventive Principle:
Principle #25Self-service

3Reliability

If alignment structures are used to keep column and base/adapter assemblies axially aligned during separation, then component damage is prevented, but device complexity increases

Engineering Contradiction:
Improvecomponent protectionVSAvoidalignment structures
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The invention employs alignment structures that guide the column assembly and base/adapter assemblies into proper axial alignment before separation occurs. By establishing alignment in advance, the need for complex real-time alignment mechanisms during separation is reduced, maintaining reliability while controlling device complexity.

Inventive Principle:
Principle #10Preliminary action

Data Source

PatentUS10758988B2Method for conducting maintenance on a chromatography column
Publication Date: 2020.09.01 CYTIVA SWEDEN AB
  • US10758988B2 patent drawing
  • US10758988B2 patent drawing
  • US10758988B2 patent drawing

AI summary

The present invention relates to methods for conducting maintenance on chromatography columns used in industrial-scale chromatography. In particular, the invention is concerned with safer methods for performing maintenance on such columns, such as cleaning and replacing bed supports, distributors, nozzles, O-rings and other column components, by the use of a handling device to support, lift, carry and manipulate such column components.