Liquid Chromatography Feeder Accuracy Check Automation
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Solution Overview
Problem
Conventional liquid chromatography devices require extensive time and resources for accuracy checks, as they necessitate frequent cleaning and preparation of multiple sample containers, leading to increased costs and inefficiencies.
Innovation Solution
The device incorporates a feeder with a tubular portion capable of retaining a sample for multiple measurements, allowing for repeated use without re-sampling, and a controller that manages the sample flow to perform accuracy checks efficiently, reducing the need for extensive cleaning and sample preparation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional liquid chromatography device performs accuracy check by preparing multiple sample containers and cleaning nozzle for each measurement, then measurement accuracy can be verified, but time consumption and operational complexity increase significantly
Solution Approach 1:
The system performs preliminary actions by automatically cleaning the suction nozzle and preparing the sample feeding path before each accuracy check measurement. The controller executes pre-programmed cleaning sequences and sample transfer operations, eliminating the need for manual intervention and reducing the time required for accuracy verification while maintaining measurement reliability.
Solution Approach 2:
The system implements self-service functionality where the device automatically performs accuracy checks using built-in sample containers and automated cleaning mechanisms. The controller manages the entire process including sample aspiration, nozzle cleaning, and repeated measurements without requiring external intervention, thereby reducing both time consumption and operational complexity.
2Measurement precision
If multiple sample containers are prepared for repeated measurements to verify accuracy, then measurement precision improves, but sample preparation time and cost increase
Solution Approach 1:
The system applies multi-functionality by using a single sample container that serves multiple purposes: it contains the sample for repeated measurements and also functions as a built-in reference standard. The automated system can perform multiple accuracy verification measurements from one container, eliminating the need to prepare multiple separate sample containers while maintaining measurement precision.
Solution Approach 2:
The system creates virtual copies of the sampling process by using the same physical sample container for multiple measurements. Instead of requiring physical copies (multiple containers), the automated system repeatedly aspirates and analyzes the same sample through controlled fluid handling, achieving the effect of multiple measurements without the overhead of preparing multiple containers.
3Reliability
If nozzle cleaning is performed frequently to maintain measurement accuracy, then measurement reliability improves, but operational time and complexity increase
Solution Approach 1:
The system replaces manual mechanical cleaning operations with an automated fluid-based cleaning mechanism. The controller directs mobile phase or cleaning solution through the suction nozzle using fluid pressure, eliminating the need for manual disassembly and mechanical cleaning steps. This substitution maintains measurement reliability while significantly reducing operational complexity and time.
Solution Approach 2:
The cleaning operation is integrated into the continuous measurement workflow rather than being performed as a separate intermittent step. The system continuously flows mobile phase or cleaning solution through the suction nozzle during and between measurements, maintaining cleanliness without interrupting the measurement sequence. This continuous approach improves reliability while reducing the perceived complexity of cleaning operations.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables quick and cost-effective accuracy checks by allowing three measurements from a single sample container, minimizing the need for frequent cleaning and reducing overall time and resource consumption.
Implementation Method 1
The suction unit 96 is used to draw the sample into the injection valve 94
Implementation Method 2
the sample drawn into the injection valve 94 is adsorbed to the filler in the column 91
Implementation Method 3
The sample adsorbed to the filler is desorbed by the eluant and separated into components within the column 91
Implementation Method 4
The detector 92 detects each separated component by e.g. measuring the absorbance
Data Source
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AI summary
An analyzing device A includes a feeder 5 connected to a container C in which a sample 7 is contained for sucking the sample 7 from the container C and feeding the sample 7, and a controller 6 for performing control for feeding from the feeder 5 to a measurer. In measuring the sample 7, the controller 6 performs control so that results of a plurality of times of measurement are obtained with respect to the single container C in which the sample 7 is contained, without changing the container C. This arrangement allows quick accuracy check.