Liquid Chromatography Flow Path Switching for Sample Dilution Modes
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Solution Overview
Problem
Conventional liquid chromatography systems are not suitable for both modes of analysis: one where the sample is diluted before introduction into the column and one where it is not, limiting their versatility.
Innovation Solution
A liquid chromatography system with a switchable flow path configuration that allows for either diluting the sample before or not diluting it before introduction into the column, using a first and second mixer positioned differently in each mode, controlled by a switch device.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If the system is configured with a fixed flow path for diluting samples before column introduction, then dilution mode analysis is achieved, but the system cannot perform undiluted sample analysis
Solution Approach 1:
The patent implements a switchable flow path configuration that allows the system to dynamically change between two operational modes: dilution mode and undiluted mode. The switch device enables the flow path to be reconfigured based on the analysis requirements, transforming a static system into a dynamic one that adapts to different sample preparation needs.
Solution Approach 2:
The patent creates a universal liquid chromatography system that can perform both dilution and undiluted sample analysis through a single instrument. By incorporating a switch device that enables flow path reconfiguration, the system achieves multi-functionality, allowing users to select the appropriate mode based on their specific analytical requirements without needing separate instruments.
2Adaptability or versatility
If the system is configured for undiluted sample analysis, then sample introduction efficiency is improved, but the system cannot perform dilution mode analysis
Solution Approach 1:
The system employs a dynamic flow path switching mechanism that allows operators to easily transition between dilution and undiluted modes based on sample characteristics and analysis requirements. The switch device simplifies operational complexity by providing a clear, selectable pathway for each mode rather than requiring complex manual reconfiguration.
3Adaptability or versatility
If a switchable flow path system is implemented to support both dilution and undiluted modes, then analysis versatility is improved, but device complexity increases
Solution Approach 1:
The patent divides the flow path into distinct segments that can be independently controlled and switched. By segmenting the flow path configuration, the system achieves versatility through modular design, where each segment can be activated or deactivated based on the selected mode, reducing the overall complexity compared to a fully integrated switchable system.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables flexible analysis modes with improved performance in both diluted and undiluted sample scenarios, reducing operational complexity and costs while maintaining analysis quality.
Implementation Method 1
a first mixer, a second mixer, and a switch device that switches a flow path from the first pump and the second pump to the column
Implementation Method 2
The first solution is supplied from a first pump. The second solution is supplied from a second pump.
Data Source
AI summary
A first solution is supplied from a first pump. A second solution is supplied from a second pump. A flow path from the first pump and the second pump to a column is switched between a first flow path and a second flow path. In the first flow path, a first mixer is located upstream of an injection part for a sample, and the second mixer is located downstream of the injection part. In the second flow path, the first mixer and the second mixer are located upstream of the injection part. The first flow path is formed in a first mode in which the sample is diluted before introduction into the column. The second flow path is formed in a second mode in which the sample is not diluted before introduction into the column.