Chromatography Stochastic Injection Parallel Analysis
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Solution Overview
Problem
Current chromatography methods for analyzing multiple samples simultaneously are time-consuming and produce poor signal-to-noise ratios, leading to inaccurate analysis and increased measurement time with the number of samples.
Innovation Solution
A method using a chromatography device with a pseudo-random binary sequence for injecting sample fractions, cross-correlating signals to reduce noise, and analyzing data to produce individual correlograms, allowing for simultaneous analysis of multiple samples with improved signal-to-noise ratios without the need for a preconcentrator.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Device complexity
If multiple samples are analyzed simultaneously using temporal multiplexing with a single injector, then device complexity is reduced, but analysis time increases with the number of samples
Solution Approach 1:
The patent segments the injection process by injecting multiple samples simultaneously through multiple injectors rather than sequentially through a single injector. Each injector introduces a different sample into the chromatography column at the same time, dividing the analysis task into parallel segments that reduce total analysis time while maintaining a relatively simple device structure.
Solution Approach 2:
The patent employs periodic pseudorandom binary sequences to control the injection timing of multiple samples. These periodic patterns allow for systematic organization of multiple simultaneous injections, enabling the system to manage complex timing requirements through repeating cycles that simplify control while achieving rapid parallel analysis.
2Productivity
If multiple samples are analyzed simultaneously using temporal multiplexing, then productivity increases, but signal-to-noise ratio deteriorates
Solution Approach 1:
The patent applies preliminary signal processing by convolving the detected signal with pseudorandom binary sequences before analysis. This preliminary action enhances the signal-to-noise ratio by correlating the expected signal pattern with the actual detected signal, allowing accurate identification of analytes even when multiple samples are analyzed simultaneously with reduced measurement time.
Solution Approach 2:
The patent uses feedback through correlation analysis where the detected signal is continuously compared against known pseudorandom sequences. This feedback mechanism allows the system to distinguish true analyte signals from noise and interference, maintaining measurement precision despite the increased productivity achieved through simultaneous multi-sample analysis.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method significantly reduces analysis time and improves signal-to-noise ratios, enabling real-time, parallel analysis of multiple samples with enhanced accuracy and efficiency.
Implementation Method 1
Gas chromatography is one of the most popular analytical chemistry tools for the analysis of volatile compounds. This technique consists in detecting peaks corresponding to vapors that are separated upstream in a capillary column usually named chromatography column.
Implementation Method 2
Another way to improve the sensitivity of a GC system is the use of a preconcentrator. This consists in amplifying the vapors concentration by collecting the analytes on an adsorbent medium during a certain period of time before quickly releasing them in the column, usually through a thermal desorption process.
Data Source
AI summary
The invention relates to a method for simultaneously analyzing at least two samples using a chromatography device comprising a chromatography column having an inlet and an outlet, and at least one detector placed at the outlet of the chromatography column, the method comprising steps of: injecting fractions of each independent sample at the inlet of the chromatography column, the fractions of each independent sample being injected according to a specific injection timing sequence derived from a pseudo-random binary sequence associated with said independent sample; recording a signal generated by said detector for a period of time at least equal to a duration of the longest of the specific injection timing sequences; cross-correlating the recorded signal and a derived correlation function, said derived correlation function being derived from the pseudo-random binary sequence associated with one of the independent samples, so as to obtain an individual correlogram signal specific to said independent sample; and analyzing data of interest of the individual correlogram signal so as to obtain an output signal indicative of a composition of the sample.