Trivalent Chromium Lactoferrin Complex for Fatty Liver
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Solution Overview
Problem
Current treatments for fatty liver disease are limited in effectiveness, and there is a need for a composition that can reduce risk factors such as obesity, hyperglycemia, hyperlipidemia, and oxidative stress to prevent and treat the disease.
Innovation Solution
A composition containing trivalent chromium lactoferrin, which forms a complex with lactoferrin and trivalent chromium compounds, enhancing absorption and utilization by the body, is administered to improve metabolic functions and reduce fatty liver disease risk factors.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional drugs (metformin, troglitazone, rosiglitazone, clofibrate, gemfibrozil, ursodeoxycholic acid, vitamin E, betaine) are used to treat fatty liver, then some therapeutic effect is achieved, but the therapeutic effect is limited and no proven effective therapy is available
Solution Approach 1:
The patent combines chromium compounds with lactoferrin to create a composite preparation that leverages the metal ion binding capacity of lactoferrin to enhance chromium absorption and biological activity. This composite approach addresses the limited effectiveness of conventional single-agent therapies by creating a synergistic formulation that improves glucose metabolism and reduces fatty liver pathology more effectively than individual drugs alone.
2Reliability
If chromium compounds are administered to improve glucose metabolism and reduce fatty liver risk factors, then absorption and utilization are enhanced through lactoferrin complex formation, but the patent requires specific formulation to achieve optimal therapeutic effect
Solution Approach 1:
Lactoferrin serves as an intermediary carrier that binds chromium ions and facilitates their absorption and transport in the gastrointestinal tract. This mediator approach solves the absorption limitation of conventional chromium supplements by using lactoferrin's natural metal ion binding capacity to protect chromium from degradation and enhance its bioavailability, thereby improving therapeutic reliability without requiring complex delivery systems.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively reduces risk factors for fatty liver disease, improves glucose tolerance, body weight, liver function, and antioxidative ability, and alleviates fatty liver disease progression.
Implementation Method 1
A composition containing trivalent chromium lactoferrin, which forms a complex with lactoferrin and trivalent chromium compounds, enhancing absorption and utilization by the body
Data Source
AI summary
A composition for preventing and treating fatty liver is disclosed. The composition includes a lactoferrin and a trivalent chromium compound. The trivalent chromium compound of the present invention is selected from the group consisting of chromium (III) chloride hexahydrate, chromium (III) chloride, chromium (III) acetate, chromium (III) sulfate, chromium picolinate, chromium nicotinate, chromium GTF, chromium yeast extract, other inorganic salts of trivalent chromium, other organic salts of trivalent chromium, and combinations thereof. The composition of the present invention can provide a beneficial effect in preventing and treating fatty liver by effectively reducing multiple risk factors of fatty liver disease.