Chrysanthemum zawadskii extract standardization via controlled extraction
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Solution Overview
Problem
There is a lack of standardized methods for producing Chrysanthemum Zawadskii extract with consistent properties, particularly in terms of linarin, chlorogenic acid, and isochlorogenic acid A content, which affects its antioxidation and pain-relieving effects.
Innovation Solution
A method involving ethanol or hot water extraction of Chrysanthemum raw materials at specific temperatures for defined durations, followed by supersonic extraction and drying, to produce an extract with standardized particle sizes and component ranges (5.5-9.9 mg/g linarin, 1.0-2.0 mg/g chlorogenic acid, and 0.8-1.6 mg/g isochlorogenic acid A), suitable for health functional foods and pharmaceutical compositions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional extraction methods are used without standardization, then the extraction process is simple and flexible, but the extract properties are inconsistent and unreliable
Solution Approach 1:
The patent applies parameter changes by establishing specific extraction conditions including temperature (40-60°C for ethanol extraction, 100-120°C for hot water extraction), time (5-7 hours for ethanol, 2-3 hours for hot water), and solvent concentration (60-80% ethanol). These standardized parameters ensure consistent extract properties while maintaining process feasibility through conventional equipment.
2Quantity of substance
If multiple extraction methods are used to improve component content, then the extract quality improves, but the production time and energy consumption increase
Solution Approach 1:
The patent employs continuous extraction processes where the solvent circulates continuously through the raw material for extended periods (5-7 hours for ethanol, 2-3 hours for hot water). This continuous action ensures complete extraction of indicator components (luteolin, chlorogenic acid, isochlorogenic acid A) while maintaining efficient time management through optimized circulation rates and temperatures.
Solution Approach 2:
The patent implements periodic extraction cycles involving repeated cycles of soaking, heating, filtering, and concentrating. The process includes periodic temperature adjustments (heating to 40-60°C for ethanol extraction, then to 100-120°C for hot water extraction) and periodic solvent replacement to maximize component recovery while managing total extraction time.
3Productivity
If high temperature extraction is used to increase extraction efficiency, then the extraction speed improves, but the thermal degradation of sensitive components occurs
Solution Approach 1:
The patent applies parameter changes by using temperature gradients - lower temperatures (40-60°C) for initial ethanol extraction to preserve heat-sensitive components, then higher temperatures (100-120°C) for hot water extraction of more stable components. This staged temperature approach maximizes extraction efficiency while preventing thermal degradation of sensitive indicator components.
Solution Approach 2:
The patent uses ethanol as an intermediary solvent that facilitates extraction at moderate temperatures (40-60°C), protecting heat-sensitive components from direct thermal exposure. Ethanol acts as a mediator that can extract components effectively without requiring the high temperatures that would degrade sensitive compounds, with hot water extraction used subsequently for more stable components.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The standardized extract exhibits consistent antioxidation and pain-relieving effects, improving oxidative damage and pain management in various diseases, with controlled particle size and properties ensuring uniformity and stability in formulations.
Implementation Method 1
performing extraction of Chrysanthemum raw material with ethanol at 40 to 60° C. for 5 to 7 hours or hot water extraction of the raw material with hot water at 100 to 120° C. for 2 to 3 hours
Implementation Method 2
immersing the raw material in ethanol followed by supersonic extraction for 2 to 3 weeks to obtain a supernatant
Implementation Method 3
extraction of Chrysanthemum raw material with ethanol at 40 to 60° C. for 5 to 7 hours or hot water extraction of the raw material with hot water at 100 to 120° C. for 2 to 3 hours
Implementation Method 4
drying and pulverizing the supernatant
Data Source
AI summary
A Chrysanthemum zawadskii (abbrev. to “Chrysanthemum”) extract with adjusted contents of each of indicator components of Chrysanthemum zawadskii (abbrev. to “Chrysanthemum”) is disclosed. The indicator components include linarin, chlorogenic acid and isochlorogenic acid. Also disclosed is a method for setting a standard for contents of the indicator components by identifying causes of the difference in properties of the Chrysanthemum extract or raw material and standardizing a preparation process from the analyzed causes of the difference in properties, to obtain a Chrysanthemum extract standardized by setting a content range of each indicator component in the Chrysanthemum raw material. Uses of the extract or a composition containing the extract are disclosed.