Ciliary Muscle Electroporation Needle Alignment on a Spherical Support
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Solution Overview
Problem
Existing electroporation devices face challenges in achieving precise and stable positioning of electrodes, risking injury and inefficient electrical field generation during product delivery into the ciliary muscle of the eye.
Innovation Solution
An electroporation device with a support having a spherical contact surface and electrodes configured to guide needles at specific angles, ensuring parallel alignment and limited risk of injury, combined with an efficient electrical field generation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional electroporation devices are used, then product delivery into the ciliary muscle is achieved, but precise and stable positioning of electrodes is difficult, increasing injury risk
Solution Approach 1:
A support structure with a spherical contact surface acts as an intermediary between the electrodes and the eye. This support structure includes insertion guides that mediate the positioning of electrode needles, ensuring they enter at controlled angles relative to the tangent plane of the eye surface. The support structure with its spherical geometry matching the eye's curvature provides stable positioning and precise angular control, reducing injury risk while maintaining effective electrode placement for electroporation.
2Power
If conventional electrode configurations are used, then electrical field generation is achieved, but efficient large electrical field generation is difficult
Solution Approach 1:
The electrode needles are configured with specific local geometric properties: they are inserted at controlled angles (less than 40°, preferably less than 30°) relative to the tangent plane of the eye surface. This local angular control ensures that the electrodes are positioned optimally within the ciliary muscle tissue, creating an efficient electrical field configuration that maximizes electroporation effectiveness while maintaining stable positioning.
Solution Approach 2:
The support structure features a spherical contact surface that matches the curvature of the eye's external surface. This spherical geometry ensures that the support structure conforms to the eye's shape, providing stable positioning and enabling the electrode needles to be inserted at consistent, controlled angles across the treatment area, thereby generating an efficient and homogeneous electrical field for electroporation.
3Ease of operation
If needle insertion angle is not controlled, then insertion is simplified, but homogeneous electroporation and parallel alignment cannot be achieved
Solution Approach 1:
Insertion guides integrated into the support structure serve as intermediaries that control the insertion angle of the electrode needles. These guides constrain the needles to enter at specific angles (less than 40°, preferably less than 30°) relative to the tangent plane of the eye surface. This intermediary mechanism simplifies the insertion operation while simultaneously ensuring precise angular control and homogeneous electrode alignment for effective electroporation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables precise and efficient electroporation of products into the ciliary muscle with reduced injury risk and homogeneous electrical field distribution.
Implementation Method 1
an electroporation device for injecting a product into an eye, and in particular into a ciliary muscle of an eye
Data Source
AI summary
An electroporation device for injecting a product into a ciliary muscle of an eye includes a support having a spherical support contact surface extending along a virtual sphere having a radius between 10 and 15 mm, a first electrode comprising a curved invasive electrode needle, a second electrode having an electrically conductive electrode contact surface, and an injection needle.