Amplifying Ciliary Muscle Signals for Accommodative IOL Control

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Solution Overview

Problem

Current accommodative intraocular lenses lack the ability to mimic the focusing mechanism of natural lenses, as they cannot be adjusted to focus on objects at varying distances like the human eye, due to the absence of a control system that harnesses and utilizes the electrical signals from ciliary muscle movements.

Innovation Solution

A control system comprising a sensing circuit to detect and an amplifier circuit to enhance the electrical signals controlling ciliary muscles, allowing these signals to control an accommodative intraocular lens, utilizing electrodes near cranial nerve III, the ciliary ganglion, or the ciliary muscles to simulate the natural lens's focusing ability.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Strength

If an accommodative IOL is implanted to replace the natural lens, then the lens transparency is improved and cataract is treated, but the focusing ability is lost because the IOL cannot be adjusted for near and distant vision

Engineering Contradiction:
Improvelens transparencyVSAvoidfocusing ability
Core Design Contradiction:
StrengthVSAdaptability or versatility

Solution Approach 1:

The patent replaces the mechanical ciliary muscle-lens capsule system with an electronic control system. Electromyographic sensors detect electrical signals from the ciliary muscles, and an artificial muscle or mechanical actuator adjusts the IOL position or shape accordingly, enabling an artificial lens to achieve focusing functionality that would otherwise be impossible with a static implant

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The system incorporates feedback by using electromyographic sensors to continuously monitor the electrical activity of the ciliary muscles. This feedback signal is processed and used to dynamically adjust the IOL position, creating a closed-loop control system that replicates the natural eye's focusing mechanism

Inventive Principle:
Principle #23Feedback

2Adaptability or versatility

If electrodes are placed near cranial nerve III or ciliary muscles to detect control signals, then the focusing control capability is improved, but the surgical complexity and risk increase

Engineering Contradiction:
Improvefocusing control capabilityVSAvoidsurgical complexity
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The patent uses the electrical signals from cranial nerve III or ciliary muscles as an intermediary carrier of control information. Rather than directly manipulating the lens, the system detects these natural neural signals and uses them to control the IOL, leveraging the body's existing control mechanism

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The system copies the natural neural control signals that normally control the ciliary muscles and uses these copied signals to drive the artificial lens adjustment mechanism, replicating the natural control pathway

Inventive Principle:
Principle #26Copying

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables the accommodative intraocular lens to adjust focus based on the brain's natural image processing signals, effectively replicating the human eye's focusing mechanism, enhancing vision by allowing the lens to change shape for both near and distant vision.

Implementation Method 1

At least one electrode located in the vicinity of cranial nerve III, the ciliary ganglion, or the ciliary muscles is used to receive the signal that controls the ciliary muscles

Methodology Applied
Scientific EffectElectrical signal detection: Conduction (electrical)

Implementation Method 2

an amplifier circuit for amplifying the sensed signal

Methodology Applied
Scientific EffectSignal amplification: Electromagnetic Induction

Data Source

PatentEP2445448B1Electrical amplification of physiologic signals for accommodative IOL control
Publication Date: 2013.04.03 ALCON RESEARCH LTD
  • EP2445448B1 patent drawingFigure 1~2
  • EP2445448B1 patent drawingFigure 3

AI summary

A control system (100) for an accommodative intraocular lens includes a sensing circuit (110) for sensing a signal that controls a ciliary muscle of an eye and an amplifier circuit (130) for amplifying the sensed signal. The output of the amplifier circuit is used to control an accommodative IOL. At least one electrode located in the vicinity of cranial nerve III, the ciliary ganglion, or the ciliary muscles is used to receive the signal that controls the ciliary muscles. A filter may also be included.