Circular Multiwell Plate Layout for Rapid Multianalyte Detection
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Solution Overview
Problem
Existing technologies for direct-to-consumer diagnostics lack the ability to perform reliable, rapid, and cost-effective multianalyte analysis at the point-of-customer-contact (POCC) site, such as in a pharmacy or general store, necessitating invasive sample collection and substantial delays in result communication.
Innovation Solution
A circular multiwell plate with concentrically arranged wells and removable chip components, each configured for specific assays, allowing parallel testing of diverse analytes with integrated quality control and synchronized data processing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If traditional multiwell plates with uniform wells are used, then device simplicity is maintained, but the ability to perform diverse assays with different well requirements is limited
Solution Approach 1:
The multiwell plate is divided into multiple zones, each containing wells with different properties (e.g., different bottom colors, different volumes, different surface treatments). This segmentation allows each zone to be optimized for specific assay types while maintaining a single integrated plate structure.
Solution Approach 2:
Different regions of the plate are赋予 different local properties - some wells have black bottoms for fluorescence assays, others have clear bottoms for absorbance assays, and varying well volumes for different sample types. This local differentiation enables diverse assay compatibility without requiring multiple separate plates.
2Reliability
If multiple separate plates are used for different assay types, then assay specificity is improved, but sample handling complexity and time increase
Solution Approach 1:
Multiple assay types are merged into a single multiwell plate by incorporating wells with different properties in different zones. This allows simultaneous performance of fluorescence assays, absorbance assays, and other test types in one plate, eliminating the need to transfer samples between multiple separate plates and reducing handling time while maintaining assay accuracy.
3Productivity
If conventional multiwell plates are used, then manufacturing simplicity is maintained, but high-throughput multianalyte detection efficiency is reduced
Solution Approach 1:
The plate design incorporates variation along multiple dimensions simultaneously - well volume, bottom color, surface treatment, and zone positioning - allowing encoding of different assay requirements within a single plate structure. This multidimensional design enables high-throughput multianalyte detection by optimizing each well's properties for its intended assay while maintaining overall plate integration.
Data Source
AI summary
Provided herein are systems, devices and methods for performing multianalyte detection in a biological sample, such as a human blood sample. Multiwell plates useful for performing multianalyte detection are also provided. The systems, devices and methods provided herein relate to the field of direct-to-consumer diagnostics (DTC diagnostics) and are useful, e.g., for facilitating consumer access to consumer healthcare and consumer wellness information. Other uses of the systems, devices and methods provided herein relate to the fields of medical research and drug discovery.