Circular Polyribonucleotides for Cosmetic Protein Delivery
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Solution Overview
Problem
Current cosmetic formulations using linear polyribonucleotides face challenges in delivering effective cosmetic proteins like collagen, keratin, and botulinum toxin to skin, hair, and nails, with limited penetration and stability, leading to suboptimal cosmetic effects.
Innovation Solution
The development of cosmetic compositions containing circular polyribonucleotides, combined with ethanol or cell-penetrating agents, which are applied topically to enhance delivery and stability, allowing for efficient penetration and expression of cosmetic proteins such as collagen, keratin, and botulinum toxin fragments.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If linear polyribonucleotides are used in cosmetic formulations, then the formulations can be applied to skin, hair, and nails, but the penetration and stability are limited resulting in suboptimal cosmetic effects
Solution Approach 1:
The patent changes the structural parameter of polyribonucleotides from linear to circular configuration. This structural parameter change fundamentally improves both stability (circular structures resist degradation better) and effectiveness (enhanced penetration and protein expression), resolving the contradiction between reliability and stability.
2Ease of operation
If linear polyribonucleotides are used, then the formulations are simple to apply, but the delivery efficiency and protein expression are insufficient
Solution Approach 1:
The structural transformation from linear to circular polyribonucleotides changes the physical-chemical parameters that govern cellular uptake and stability. This parameter change enhances delivery efficiency and productivity while maintaining ease of application, as the circular structure can be incorporated into existing topical formulation protocols.
3Reliability
If higher concentrations of polyribonucleotides are used to improve cosmetic effects, then the effectiveness increases, but the stability and persistence in tissues are reduced
Solution Approach 1:
The circular configuration changes the degradation kinetics parameter of polyribonucleotides. This structural parameter enables prolonged tissue persistence even at effective concentrations, as circular structures are resistant to exonuclease degradation and maintain structural integrity longer, thus resolving the contradiction between effectiveness and duration.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The use of circular polyribonucleotides with ethanol or cell-penetrating agents significantly improves the delivery and stability of cosmetic proteins, resulting in enhanced cosmetic effects, including improved skin appearance, increased moisturization, and reduced wrinkles, with increased translation efficiency and prolonged persistence in tissues.
Implementation Method 1
compositions and cosmetic compositions include a cell-penetrating agent and the circular polyribonucleotides
Implementation Method 2
The cosmetic compositions can be applied to epithelial cells for delivery of the cosmetic circular polyribonucleotide
Data Source
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AI summary
Disclosed herein are methods and compositions for delivery of polyribonucleotide. In some cases, the methods and compositions provided herein are suitable for in vivo delivery of polyribonucleotides. In certain aspects, also disclosed herein are cosmetic compositions for delivery of polyribonucleotide having cosmetic effects.