Circulating miRNA Biomarker Assessment for Personalized Cardiovascular Exercise
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Solution Overview
Problem
Current methods lack an effective way to assess and personalize physical activity programs for individuals to reduce their risk of developing cardiovascular disease, as they do not account for individual variations in miRNA responses to exercise.
Innovation Solution
A method involving the determination of circulating miRNA concentrations in fluid samples before and after physical activity, specifically focusing on hsa-miRNA-1, hsa-miRNA-24, hsa-miRNA-96, hsa-miRNA-143, hsa-miRNA-98, hsa-miRNA-125a, and hsa-miRNA-132, to compare changes and tailor physical activity programs based on these changes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If general physical activity recommendations are provided without individual assessment, then implementation is simple and easy to follow, but the effectiveness in reducing individual cardiovascular risk is insufficient
Solution Approach 1:
The patent replaces complex mechanical/physiological assessment systems with a biochemical marker system. Instead of monitoring multiple physiological parameters during exercise, the invention uses circulating miRNA concentration changes as a surrogate marker to assess individual cardiovascular response to exercise, simplifying the assessment while improving reliability
Solution Approach 2:
The patent introduces circulating miRNAs as intermediary biomarkers that mediate between physical exercise and cardiovascular health outcomes. These miRNAs serve as measurable indicators that reflect individual cardiovascular response to exercise, enabling personalized program design without direct complex physiological monitoring
2Adaptability or versatility
If physical activity programs are personalized based on detailed individual assessment, then effectiveness in reducing cardiovascular risk is improved, but the assessment and program design becomes more complex and time-consuming
Solution Approach 1:
The patent extracts the essential information needed for personalization from complex physiological responses and concentrates it into a single measurable parameter: the change in circulating miRNA concentration. This extraction allows rapid assessment while maintaining personalization capability
Solution Approach 2:
The patent changes the assessment parameter from multiple physiological measurements to a single biochemical marker (circulating miRNA concentration). This parameter change simplifies the assessment process while providing sufficient information for program personalization
Data Source
AI summary
The present invention relates to a method for establishing an individual physical activity program for a subject for reducing an individual risk of the subject for developing a cardiovascular disease, comprising the following steps: (i) determining the concentration of at least one circulating miRNA in at least one fluid sample obtained from the subject, at least before and after the subject has conducted physical activity; wherein the at least one circulating miRNA is selected from certain miRNAs; (ii) comparing the in step (i) determined concentration(s), wherein the result of this comparison is indicative of whether said subject has an individual risk for developing a cardiovascular disease under certain conditions; and (iii) establishing the individual physical activity program for the subject based on the result of step (ii). The present invention further relates to various uses of miRNAs in any of the methods according to the present invention.