Automated Citrate Anticoagulation Infusion Control
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Solution Overview
Problem
Current regional citrate anticoagulation (RCA) methods in clinical settings rely on trial-and-error for adjusting citrate and calcium infusion rates, limiting their application due to the need for frequent ionized calcium monitoring, especially in modes other than continuous venovenous hemodialysis (CVVHD).
Innovation Solution
A method and system for automated control of citrate and calcium pumps in RCA systems, using specific equations to determine citrate infusion volume and calcium supplementation based on blood flow velocity, red blood cell hematocrit, and dialyzer membrane area, applicable to CVVHDF and intermittent hemodialysis (iHD) modes, ensuring precise and stable infusion speeds.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If trial-and-error method is used to adjust citrate and calcium infusion rates, then clinical flexibility is maintained, but the application of RCA technology is limited due to frequent monitoring requirements
Solution Approach 1:
The system performs self-adjustment by automatically calculating and adjusting citrate and calcium infusion rates based on real-time monitoring data, eliminating the need for manual trial-and-error adjustments and expanding RCA application scope
Solution Approach 2:
The system continuously monitors ionized calcium levels and uses this feedback to automatically adjust infusion rates, replacing manual monitoring with an automated closed-loop control system that maintains stability without frequent interventions
2Manufacturing precision
If automated control system is implemented, then infusion precision and stability are improved, but the system complexity increases
Solution Approach 1:
The patent replaces manual mechanical adjustment with an automated control system that uses electronic sensors, processors, and actuators to precisely control infusion rates, achieving higher precision while managing complexity through integration
Solution Approach 2:
The control system integrates multiple functions including monitoring, calculation, adjustment, and alarm generation into a single unified system, reducing overall complexity by consolidating what would otherwise be separate components
3Reliability
If frequent ionized calcium monitoring is performed, then patient safety is ensured, but the trial-and-error adjustment process becomes more time-consuming
Solution Approach 1:
The system automatically processes monitoring data and adjusts infusion rates without requiring manual intervention, ensuring patient safety through continuous monitoring while eliminating the time loss associated with manual trial-and-error adjustments
Solution Approach 2:
The system maintains continuous automated monitoring and adjustment, ensuring uninterrupted patient safety monitoring while eliminating the intermittent nature of manual adjustments and their associated delays
Data Source
AI summary
A method for controlling an infusion rotation speed of a citrate pump comprises: collecting parameters of the regional citrate anticoagulation infusion system (S101), the parameters include blood flow velocity and red blood cell hematocrit; determining a citrate infusion volume per unit time based on the parameters (S102); and controlling the infusion rotation speed of the citrate pump based on the citrate infusion volume per unit time (S103). A method for controlling an infusion rotation speed of a calcium pump includes: determining an amount of calcium supplementation required for the regional citrate anticoagulation infusion system (S201); and controlling the infusion rotation speed of the calcium pump according to the amount of calcium supplementation (S202). The citrate infusion volume per unit time and the amount of calcium supplementation required by the regional citrate anticoagulation infusion system is determined through specific formulas.