Closed-Loop Insulin Dosing Without Recent User Input
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Solution Overview
Problem
People with diabetes face a significant cognitive and emotional burden in managing their intensive insulin therapy, requiring frequent dosing determinations and recalibration of therapeutic parameters based on various factors such as diet, exercise, and lifestyle changes.
Innovation Solution
A method that uses previous insulin delivery data from an insulin pump and estimated glucose data from a continuous glucose monitor to determine an insulin delivery amount without relying on user-specific behavioral or physiological data entered through a user interface within the previous 6 hours, and communicates this amount to the insulin pump.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If multiple daily injections or continuous insulin pump therapy are used to achieve glycemic control, then blood glucose levels can be maintained within safe limits, but the cognitive burden and complexity of managing dosing determinations and recalibration increase significantly
Solution Approach 1:
The insulin delivery system automatically adjusts insulin delivery based on glucose sensor data without requiring user intervention for dosing calculations or parameter recalibration. The system self-regulates by receiving glucose measurements, processing them through control algorithms, and autonomously determining insulin delivery amounts, thereby eliminating the cognitive burden of manual therapy management while maintaining reliable glycemic control
Solution Approach 2:
The system implements closed-loop feedback by continuously monitoring glucose levels via sensor data and using this information to automatically adjust insulin delivery. The control processor receives real-time glucose measurements, compares them to target ranges, and dynamically modifies insulin pump operation accordingly, creating a self-correcting system that maintains glycemic control without user intervention
2Reliability
If frequent dosing determinations and recalibration are required to maintain effective insulin therapy, then glycemic control can be optimized, but the time and cognitive effort required from the user increase
Solution Approach 1:
The system maintains continuous therapeutic action by operating as a closed-loop system that constantly monitors glucose levels and continuously adjusts insulin delivery without interruption. The glucose sensor provides ongoing measurements and the control processor continuously processes this data to maintain optimal insulin delivery, eliminating the need for discrete dosing events and user intervention throughout the day
3Ease of operation
If automated insulin delivery systems are implemented to reduce user burden, then cognitive load decreases, but the system complexity and dependency on technology increase
Solution Approach 1:
The system merges multiple functions into a single integrated automated system: the glucose sensor combines detection and data transmission functions, the control processor integrates data processing and decision-making algorithms, and the insulin pump unifies delivery control and monitoring. This consolidation of sensing, processing, and actuation functions into one cohesive system reduces user burden while managing complexity through functional integration rather than separate components
Data Source
AI summary
Some embodiments include burden-free insulin delivery systems and methods. In some embodiments, a method may include receiving previous insulin delivery data at a user device from an insulin pump; receiving estimated glucose data at the user device from a continuous glucose monitor; determining an insulin delivery amount based on the previous insulin delivery data and the estimated glucose data to bring the estimated glucose data closer to a target glucose value without using any user-specific behavioral data physically entered by a user through a user interface of the user device within a previous period of time, the previous period of time being less than six hours; and communicating the insulin delivery amount to the insulin pump.