Closed-System IV Line Priming With Negative-Pressure Collection

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Solution Overview

Problem

Healthcare providers are at risk of exposure to hazardous drugs during the reconstitution, transportation, and administration processes, particularly when priming intravenous lines with chemotherapy drugs, as releasing these drugs into unsealed receptacles poses health hazards.

Innovation Solution

A closed system transfer device with connectors and collection devices is used to prime intravenous lines, allowing fluid transfer into a collection container with negative pressure, preventing leakage and ensuring safe handling of hazardous drugs.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If hazardous drugs are pushed through the intravenous line to remove air and fluid, then the intravenous line is effectively primed, but the hazardous drugs are released into an unsealed receptacle presenting risks to health care providers and patients

Engineering Contradiction:
Improvepriming effectivenessVSAvoidhealthcare provider exposure risk
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

A closed receptacle serves as an intermediary container to receive hazardous drugs during priming. The receptacle is connected to the intravenous line through a closed system transfer device, allowing hazardous drugs to be contained and collected safely rather than released into the environment. This mediator enables effective priming while protecting healthcare providers from exposure.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The closed receptacle creates a contained environment that isolates hazardous drugs from the external environment. By maintaining a closed system during the priming process, the hazardous drugs remain confined within the controlled environment of the receptacle, preventing exposure to healthcare providers and patients while still allowing the priming function to be performed.

Inventive Principle:
Principle #39Inert atmosphere (Inert environment)

2Object-affected harmful factors

If a closed system transfer device and collection device are used to contain hazardous drugs, then healthcare provider safety is improved, but the device complexity increases

Engineering Contradiction:
Improvehealthcare provider exposure riskVSAvoidpriming system complexity
Core Design Contradiction:
Object-affected harmful factorsVSDevice complexity

Solution Approach 1:

The closed system transfer device and collection device are merged into an integrated assembly where the collection device is directly connected to the transfer device. This combination allows the priming function, containment function, and collection function to be performed by a single integrated system rather than separate components, reducing overall complexity while maintaining safety.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The closed system transfer device serves multiple functions: it enables priming of the intravenous line, contains hazardous drugs during transfer, and connects to the collection device for safe disposal. This multi-functionality reduces the need for separate dedicated devices for each function, thereby simplifying the overall system while maintaining healthcare provider protection.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The system effectively primes intravenous lines while containing hazardous drugs, reducing exposure risks for healthcare providers and ensuring safe disposal by preventing leaks and spills.

Implementation Method 1

The collection container defines a volume having a negative pressure

Methodology Applied
Scientific EffectNegative pressure: Pressure Gradient

Data Source

PatentUS12408852B2System and method for priming an intravenous line
Publication Date: 2025.09.09 BECTON DICKINSON & CO
  • US12408852B2 patent drawing
  • US12408852B2 patent drawing
  • US12408852B2 patent drawing

AI summary

A system for priming an intravenous line includes a closed system transfer device having a first connector and a second connector, a connector device having a first connector and a second connector, a collection device having a first connector, a cannula having a distal end, and a sleeve having a first position where the distal end of the cannula is positioned within the sleeve and a second position where the distal end of the cannula is positioned outside of the sleeve, and at least one collection container having a closure. The collection container defines a volume having a negative pressure, with the cannula of the collection device configured to pierce the closure of the collection container.