Clot Retrieval Device Segmentation for Stroke Revascularization
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Solution Overview
Problem
Current clot removal devices for ischemic stroke patients face challenges in achieving high reperfusion rates and safety, with stent-like retrievers often causing vessel trauma due to variable radial force requirements and limited effectiveness across different clot types, leading to suboptimal revascularization outcomes.
Innovation Solution
A clot retrieval device with a self-expandable framework and porous inner body flow channel, designed to deliver a revascularization device that can achieve a 63.2% revascularization rate (mTICI ≥2b) on the first pass, with a safety outcome of 1.6% 24-hour symptomatic intracerebral hemorrhage, suitable for large-vessel occlusions in the carotid, middle cerebral, and vertebral arteries.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If stent-like retriever devices are used to remove clots, then clot removal capability is improved, but vessel trauma increases due to excessive radial force
Solution Approach 1:
The device divides the clot engagement function into two separate components: an inner body with porous flow channels for clot capture and an outer tubular body for structural support and radial force application. This segmentation allows each component to be optimized independently - the inner body can be designed for gentle clot entrapment while the outer body provides controlled radial force, resolving the contradiction between effective clot removal and vessel trauma prevention.
Solution Approach 2:
The device applies different radial force characteristics to different regions: the outer tubular body provides radial force for clot engagement while the inner porous body allows blood flow and reduces localized pressure on the vessel wall. This local differentiation of functional properties enables effective clot removal in some regions while minimizing vessel trauma in others.
2Adaptability or versatility
If radial force is increased to grip all clot types, then clot retrieval effectiveness is improved, but device complexity increases
Solution Approach 1:
The dual-body structure serves multiple functions simultaneously: the outer tubular body provides radial expansion force for gripping various clot types, while the inner porous body enables blood flow passage and clot fragmentation. This multi-functionality allows a single device design to handle diverse clot morphologies (soft/fresh, hard/old, long/short) without requiring multiple specialized devices, thereby improving versatility without proportionally increasing complexity.
3Reliability
If multiple passes are made to achieve revascularization, then revascularization completeness is improved, but treatment time increases
Solution Approach 1:
The device is designed to perform preliminary clot capture and revascularization actions in a single pass through the occluded vessel. The expandable outer body and porous inner body are configured to work together during the first passage to achieve sufficient reperfusion (mTICI ≥2b), reducing the need for repeated passes and thereby minimizing treatment time while maintaining revascularization completeness.
Data Source
AI summary
Methods and systems for using a clot retrieval device for treating a clot in a blood vessel for use in the treatment of ischemic stroke to achieve a clinically effective revascularization or perfusion rate. Perfusion is restored to the blood vessel by passing the clot retrieval device by, through, or about the thrombus and removing the revascularization device to achieve, on the first pass, approximately a 63.2% final revascularization rate under the modified treatment in cerebral infarction score of equal to or greater than a grade of 2b (mTICI ≥2b) for the plurality of human patients with one or more cerebral occlusions within a predetermined time period of natural stroke symptom onset.