Carboxymethylcellulose Foam Hemostasis and Resorption Control
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Solution Overview
Problem
Current bioresorbable packing and stents lack effective hemostatic properties and controlled resorption times, particularly for post-operative and drug delivery applications, where they are needed to manage bleeding and prevent tissue adhesion.
Innovation Solution
A flexible bioresorbable foam made from 100% carboxymethylcellulose with dehydrothermal crosslinking and lyophilization processes, providing hemostatic properties and a controlled in-vivo residence time of about 14 days, suitable for various medical uses including nasal packing, sinus stents, and drug delivery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional bioresorbable packing materials (hyaluronic acid, polysaccharides) are used, then biocompatibility and tissue compatibility are improved, but hemostatic properties are insufficient
Solution Approach 1:
The patent combines carboxymethylcellulose (CMC) with collagen and/or fibrin in a foam structure to create a composite material that simultaneously provides biocompatibility, hemostatic properties, and controlled resorption. The CMC matrix offers biocompatibility and resorption control, while the collagen/fibrin components provide hemostatic activity through thrombin generation and platelet activation.
Solution Approach 2:
The foam structure provides a porous network that facilitates hemostasis through thrombin generation and platelet aggregation within the void spaces, while maintaining controlled resorption. The porosity allows for fluid penetration and cellular infiltration, enabling the material to perform multiple functions simultaneously.
2Duration of action of stationary object
If crosslinked HA materials are used, then insolubility and longer in-vivo residence time are improved, but hemostatic properties remain insufficient
Solution Approach 1:
The patent creates a composite where crosslinked CMC provides extended residence time (14 days), while incorporated collagen and fibrin components maintain hemostatic activity throughout the resorption period. The synergistic combination ensures both prolonged presence and continuous functional performance.
Solution Approach 2:
The foam structure maintains continuous hemostatic activity throughout its 14-day residence time through sustained thrombin generation and platelet activation. The porous network continuously facilitates these processes from insertion until complete resorption, ensuring uninterrupted useful action.
3Object-generated harmful factors
If collagen is used as bioresorbable material, then hemostatic properties are improved, but controlled resorption time is insufficient
Solution Approach 1:
The patent combines collagen (providing hemostasis) with CMC (providing controlled resorption) in a foam matrix. The CMC component regulates the resorption rate to achieve the desired 14-day timeline, while collagen maintains hemostatic functionality throughout this period through thrombin generation and platelet activation.
Solution Approach 2:
The patent modifies the resorption parameters of collagen by incorporating it into a CMC foam matrix, which controls the degradation rate and extends the residence time to 14 days. This parameter change allows the material to maintain hemostatic properties for an extended period rather than rapid resorption.
4Ease of operation
If flexible foam is made from carboxymethylcellulose, then ease of handling and contouring are improved, but hemostatic properties must be demonstrated
Solution Approach 1:
The patent creates a flexible CMC-based foam composite incorporating collagen and/or fibrin that maintains ease of handling and contouring while demonstrating hemostatic properties through thrombin generation and platelet aggregation. The flexible foam structure allows for easy manipulation during surgery, and the composite composition ensures functional hemostatic performance.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The foam effectively controls bleeding, prevents adhesion, and provides a controlled resorption time, making it suitable for diverse medical applications while being easy to handle and contour within body cavities.
Implementation Method 1
dehydrothermal crosslinking and lyophilization processes
Implementation Method 2
dehydrothermal crosslinking and lyophilization processes
Implementation Method 3
flexible bioresorbable foam... providing hemostatic properties and a controlled in-vivo residence time of about 14 days
Data Source
AI summary
A method of making a flexible bioresorbable foam comprising the steps of: a) providing a carboxymethylcellulose component, b) mixing the carboxymethylcellulose component with water to form a suspension, c) freezing and lyophilizing the carboxymethylcellulose at 0 degrees C or below, and d) crosslinking and sterilizing the carboxymethylcellulose with use of gamma and ebeam irradiation past the point of sterilization such that the foam has an in-vivo residence time between 3 and 6 days.