Portable CMOS Analyte Detection Device with Balanced Light Sensing
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Solution Overview
Problem
Current systems for determining analyte concentrations in bodily fluid samples are limited by their inability to efficiently detect multiple analytes simultaneously, require non-portable equipment, and are not suitable for use with ambient or low-level light.
Innovation Solution
A portable, battery-operated device equipped with a surface for conducting detection reactions, light sensors, and a light source, which uses a balanced detection method and CMOS image sensing to detect multiple analytes in a single biological sample within less than an hour.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If current systems are used to determine analyte concentrations, then measurement capability is provided, but the systems are not suitable for portable, battery-operated use and cannot detect multiple analytes simultaneously
Solution Approach 1:
The patent combines multiple analyte detection capabilities into a single portable device by integrating a microarray substrate with multiple capture agents, a light source, and photodetectors into one unified system. This merging allows simultaneous detection of multiple analytes without requiring separate complex equipment for each analyte, directly resolving the contradiction between versatility and device complexity.
Solution Approach 2:
The portable device is designed with universal functionality to detect multiple different analytes (such as troponin, myoglobin, and BNP) using a single device platform. The microarray substrate can be configured with various capture agents to detect different analytes, making the device multi-functional and adaptable to different diagnostic needs while maintaining portability, thus resolving the contradiction between adaptability and device complexity.
2Ease of operation
If conventional detection systems are used, then analyte measurement is achieved, but the systems require non-portable equipment and cannot operate with ambient or low-level light
Solution Approach 1:
The patent employs parameter changes by using enzymatic amplification to convert low-level light signals into measurable electrical signals. The enzyme-linked detection system amplifies the signal from bound analytes, enabling precise measurement even with ambient or low-level light conditions. This parameter transformation allows the device to maintain measurement precision while operating portably with minimal light requirements, resolving the contradiction between ease of operation and measurement precision.
3Loss of information
If multiple analytes are detected simultaneously, then diagnostic information is enhanced, but detection time and processing complexity increase
Solution Approach 1:
The patent applies preliminary action by pre-configuring the microarray substrate with multiple capture agents specific to different analytes before sample introduction. This pre-prepared configuration allows simultaneous detection of multiple analytes in a single sample application without requiring sequential processing or complex post-detection analysis, thereby enhancing information completeness while minimizing detection time and resolving the contradiction between information completeness and time loss.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device enables fast, portable, and efficient detection of multiple analytes in a single sample, using ambient light and minimal power, thereby facilitating accurate prognosis and diagnosis in various clinical settings.
Implementation Method 1
one or more detection sensors to sense light associated with the detection region; one or more reference sensors to sense light associated with the reference region; and at least one light source to illuminate the detection region and the reference region
Data Source
AI summary
A detection device and associated systems and methods for detecting analytes from a multiplex reaction are described. In particular, a device for conducting at least one detection reaction using a modified ELISA method including a surface with a detection region and a reference region, a detection sensor, and a light source. The detection device may include a complementary metal-oxide-semiconductor (CMOS) image sensor. The device may be used to measure and report discrete quantities or combinations of discrete analytes, providing information to aid in the prognosis and/or diagnosis of altered states of health in vertebrates.