Co-crystal Insecticide Formulation for Controlled Release
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Solution Overview
Problem
Existing insecticides with high water solubility face challenges in maintaining long-term efficacy while minimizing phytotoxicity and elution rates, which affect their effectiveness and safety for plants and animals.
Innovation Solution
A co-crystal formed by combining a diamide-based insecticidal-active ingredient, such as cyantraniliprole, chlorantraniliprole, or cyclaniliprole, with a neonicotinoid-based ingredient like acetamiprid, where the molar ratio is controlled between 0.3 to 3, is produced through methods involving suspension in a solvent and heating, reducing the water solubility of the neonicotinoid and enhancing the insecticidal effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If neonicotinoid-based insecticides with high water solubility are used, then insecticidal efficacy is improved, but elution rate increases causing phytotoxicity and reduced long-term effectiveness
Solution Approach 1:
The patent creates a co-crystal composite material combining neonicotinoid-based insecticide (acetamiprid) with diamide-based insecticide (cyantraniliprole, chlorantraniliprole, or cyclaniliprole). This composite structure modifies the solubility and release characteristics of the neonicotinoid component, reducing its elution rate while maintaining insecticidal efficacy. The co-crystal form allows the high-solubility neonicotinoid to be delivered at controlled rates, preventing phytotoxicity while ensuring long-term effectiveness.
2Reliability
If water solubility of insecticidal ingredients is increased, then initial insecticidal effect is improved, but long-term maintenance of effect deteriorates due to rapid elution
Solution Approach 1:
The patent changes the physical and chemical parameters of the neonicotinoid insecticide by forming a co-crystal structure. This transformation alters the solubility profile and release kinetics of the active ingredient. The co-crystal form maintains adequate water solubility for initial efficacy while providing controlled release characteristics that extend the duration of action, thereby solving the contradiction between initial effect and long-term maintenance.
3Reliability
If concentration of insecticidal application is increased, then immediate pest control is improved, but phytotoxicity to useful plants increases
Solution Approach 1:
The patent applies preliminary action by pre-formulating the neonicotinoid insecticide in a co-crystal structure before application. This pre-modification of the chemical form ensures controlled release characteristics are built into the product itself, allowing effective pest control at lower application concentrations without risking phytotoxicity. The co-crystal structure acts as a built-in release control mechanism that prevents excessive concentration buildup in plants.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The co-crystal formulation achieves controlled elution of the insecticidal ingredients, maintaining excellent insecticidal effects over a long period without causing phytotoxicity to useful plants, as demonstrated by differential scanning calorimetry and X-ray diffraction results.
Implementation Method 1
acetamiprid and a diamide-based insecticidal-active ingredient, selected from cyantraniliprole, chlorantraniliprole and cyclaniliprole, form a co-crystal
Implementation Method 2
suspending the diamide-based insecticidal-active ingredient and the neonicotinoid-based insecticidal-active ingredient in a solvent to obtain a suspension, and heating and stirring the suspension
Implementation Method 3
heating and stirring the suspension
Data Source
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AI summary
A co-crystal composed of a diamide-based insecticidal-active ingredient and a neonicotinoid-based insecticidal-active ingredient is provided as a co-crystal which exhibits excellent insecticidal effects over a long period of time while reducing the occurrence of chemical damage on useful plants. The co-crystal is obtained by a method including heating and stirring of a suspension obtained by suspending the diamide-based insecticidal-active ingredient and the neonicotinoid-based insecticidal-active ingredient in a solvent such as water.