Blood Coagulation Analysis Device Interference Correction
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Solution Overview
Problem
Existing blood coagulation analysis devices face challenges in accurately measuring coagulation time due to interference substances like hemoglobin, bilirubin, and chyle, leading to wasted reagents and measurement errors, particularly when interference substances are present in high concentrations.
Innovation Solution
An automatic analysis device with a light measuring unit, amplification circuit unit, and arithmetic operation unit that calculates a correction signal to adjust for interference, allowing for expanded measurement range and accurate coagulation time measurement regardless of reagent mixing status, using a fixed amplification rate and correcting measurement signals to minimize interference influence.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If optical information is acquired after mixing coagulation analysis reagent into blood specimen to measure interference substance degree, then measurement range of interference substance can be expanded through dilution, but coagulation analysis reagent is wasted when measurement must be stopped due to high interference substance content
Solution Approach 1:
The patent performs preliminary measurement of interference substance degree using optical information from the blood specimen before mixing the coagulation analysis reagent. This preliminary action allows the system to determine whether the interference substance content is within the measurable range, thereby preventing waste of coagulation analysis reagent when the content is too high, while still enabling measurement of specimens with appropriate interference levels.
2Loss of substance
If optical information is acquired before mixing coagulation analysis reagent into blood specimen to measure interference substance degree, then coagulation analysis reagent consumption can be suppressed, but measurement range is limited when interference substance content is large
Solution Approach 1:
The system performs preliminary measurement of interference substance degree before reagent mixing to suppress reagent consumption. When the preliminary measurement shows interference substance content is within the acceptable range, the system proceeds with the coagulation analysis, thereby avoiding unnecessary reagent waste while ensuring measurement capability.
3Object-affected harmful factors
If light with long wavelength is used for measurement, then influence of hemoglobin and bilirubin interference substances is reduced, but measurement sensitivity decreases
Solution Approach 1:
The patent uses light with a wavelength of 660nm for optical measurement, which is a specific parameter choice that balances the trade-off between reducing interference from hemoglobin and bilirubin while maintaining adequate measurement sensitivity. This wavelength parameter was selected to optimize the measurement conditions for blood coagulation analysis.
4Quantity of substance
If amplification rate of detection circuit is adjusted to detect interference substances in specimen with high concentration, then measurement range is expanded, but sensitivity at coagulation time measurement differs according to interference substance degree causing measurement errors
Solution Approach 1:
The system performs preliminary measurement of interference substance degree before the coagulation analysis measurement. Based on this preliminary information, the system can determine whether the specimen is suitable for measurement and adjust measurement parameters accordingly, ensuring that the main coagulation time measurement is performed under appropriate conditions with consistent sensitivity.
Solution Approach 2:
The system uses the measurement result of interference substance degree as feedback to determine whether to proceed with coagulation analysis and how to configure the measurement parameters. This feedback mechanism ensures that specimens with excessively high interference substance content are identified and handled appropriately, preventing measurement errors in the coagulation time determination.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution enables expanded measurement range and accurate coagulation time measurement under the same conditions, reducing reagent waste and measurement errors, while maintaining efficiency without complex device configurations.
Implementation Method 1
a light source which irradiates the reaction container with light, and a detection unit which detects scattered light from the specimen in the reaction container
Data Source
AI summary
The automatic analysis device is provided with (1) a measurement mechanism having a light measuring unit having a reaction container in which the sample is dispensed, a light source which emits light to the reaction container, and a detection unit that detects scattered light from the sample in the reaction container, (2) an amplifier circuit unit having an adder-subtractor that adds or subtracts a correction signal to or from a first measurement signal from the detection unit, and an amplifier circuit which amplifies the output signal by the adder-subtractor at a fixed amplification rate to output a second measurement signal, and (3) an arithmetic operation unit which calculates the correction signal on the basis of a difference between the signal level of the second measurement signal and a target value, and which executes an analysis action based on the second measurement signal after correction by means of the correction signal.